{"id":"W2895925640","doi":"10.1016/s2468-1253(18)30306-6","title":"A composite disease activity index for early drug development in ulcerative colitis: development and validation of the UC-100 score","year":2018,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Robarts Clinical Trials","funders":"AbbVie Canada; Shire; UCB; Takeda Canada; Covidien; Teva Pharmaceutical Industries; Merck; GlaxoSmithKline","keywords":"Medicine; Ulcerative colitis; Internal medicine; Odds ratio; Logistic regression; Gastroenterology; Receiver operating characteristic; Clinical trial; Colitis; Placebo; Surgery; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004847514,0.0008281199,0.00127944,0.002436501,0.0002542187,0.001868182,0.0007991798,0.0006201037,0.001484465],"category_scores_gemma":[0.01170279,0.0002743579,0.001055842,0.001741208,0.0004332454,0.0008187118,0.001164307,0.001891178,0.0006536034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000731625,"about_ca_system_score_gemma":0.001201927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001926792,"about_ca_topic_score_gemma":0.003213227,"domain_scores_codex":[0.9964945,0.001226498,0.000393201,0.000250341,0.001502811,0.000132705],"domain_scores_gemma":[0.991015,0.003168839,0.002402917,0.0005159018,0.00213116,0.000766157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003489367,0.0006305584,0.7155321,0.0004390605,0.001646303,0.0001212966,0.0001003132,0.002909863,0.002608257,0.0009981389,0.006783578,0.2647411],"study_design_scores_gemma":[0.0008955208,0.003002276,0.9618021,0.0002580871,0.001043359,0.000866951,0.0001136974,0.01442309,0.003404733,0.001952563,0.01213188,0.0001057524],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9058009,0.02723947,0.02548332,0.003120318,0.000798574,0.0009277451,0.01108966,0.000727949,0.02481194],"genre_scores_gemma":[0.9707053,0.003695809,0.01742838,0.0004568083,0.0001830138,0.0003518369,0.005079411,0.0000533967,0.002046022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004847514,"threshold_uncertainty_score":0.02563637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01407274276153977,"score_gpt":0.2475834282213601,"score_spread":0.2335106854598203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}