{"id":"W2895926369","doi":"10.3390/v10100568","title":"Rapid Construction of a Replication-Competent Infectious Clone of Human Adenovirus Type 14 by Gibson Assembly","year":2018,"lang":"en","type":"article","venue":"Viruses","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Eye Institute; National Natural Science Foundation of China","keywords":"Biology; Virology; Plasmid; Rolling circle replication; clone (Java method); PBR322; Virus; Restriction enzyme; Genome; Viral replication; Origin of replication; Gene; Genetics; DNA replication","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002557512,0.0001176027,0.0001744916,0.00008206137,0.00007619384,0.000009154692,0.0001881035,0.0001250778,0.0001397392],"category_scores_gemma":[0.000106725,0.0001171353,0.00005950937,0.000204157,0.0003420533,0.000005723783,0.00006565356,0.0000686699,0.00002533399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001622853,"about_ca_system_score_gemma":0.00008990524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001409576,"about_ca_topic_score_gemma":0.00009967411,"domain_scores_codex":[0.998937,0.00009912336,0.000287352,0.0003195875,0.000186746,0.0001702119],"domain_scores_gemma":[0.9987031,0.00001511973,0.000194403,0.0006713071,0.0003633741,0.00005267064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006130458,0.0001176621,0.00346943,0.00001923867,0.0000855926,1.903479e-7,0.00002605264,0.000001243744,0.9863857,0.00008960885,0.002828476,0.006363731],"study_design_scores_gemma":[0.0005055526,0.004802838,0.0007520235,0.00001159008,0.00001433224,0.000005737615,0.00001996482,0.000003876084,0.9803892,0.00005083729,0.01333403,0.0001100165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973334,0.001304561,0.00008655593,0.00002932895,0.0001083744,0.0001854878,0.0000428251,0.00001691718,0.0008925457],"genre_scores_gemma":[0.9988632,0.0004526635,0.0001662087,0.0001423568,0.0001712811,0.00001415009,0.00006152868,0.00002356145,0.0001050766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01050555,"threshold_uncertainty_score":0.4776639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02938442881320279,"score_gpt":0.329638043594611,"score_spread":0.3002536147814082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}