{"id":"W2895926369","doi":"10.3390/v10100568","title":"Rapid Construction of a Replication-Competent Infectious Clone of Human Adenovirus Type 14 by Gibson Assembly","year":2018,"lang":"en","type":"article","venue":"Viruses","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Eye Institute; National Natural Science Foundation of China","keywords":"Biology; Virology; Plasmid; Rolling circle replication; clone (Java method); PBR322; Virus; Restriction enzyme; Genome; Viral replication; Origin of replication; Gene; Genetics; DNA replication","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00144636,0.001165605,0.001930656,0.001267656,0.0007657562,0.0008812946,0.001269177,0.0006950072,0.002092686],"category_scores_gemma":[0.0009820355,0.001244537,0.00116627,0.000965164,0.0005586745,0.0004465228,0.001489581,0.001874774,0.003384456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006377223,"about_ca_system_score_gemma":0.0005785906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002646247,"about_ca_topic_score_gemma":0.002744643,"domain_scores_codex":[0.998862,0.0002595138,0.0001425644,0.0002444675,0.0002937375,0.0001977558],"domain_scores_gemma":[0.9996209,0.00008646048,0.0000485512,0.00006763217,0.0001001614,0.00007628618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002237342,0.0001389554,0.0005909561,0.0004449596,0.0000444181,0.0002621012,0.0003993024,0.000477612,0.9844012,0.001469015,0.001079129,0.01046857],"study_design_scores_gemma":[0.0002526609,0.001636719,0.004848647,0.0001328929,0.0003093563,0.0009677052,0.0003379408,0.01284372,0.8912655,0.0008074091,0.08641169,0.0001857439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5625265,0.006468189,0.3992357,0.000484557,0.0007441103,0.006661453,0.006626512,0.003536601,0.01371643],"genre_scores_gemma":[0.5153939,0.005983361,0.417708,0.0002507811,0.00008824477,0.003702304,0.03269036,0.0009951842,0.02318792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002646247,"threshold_uncertainty_score":0.007649183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02938442881320279,"score_gpt":0.329638043594611,"score_spread":0.3002536147814082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}