{"id":"W2895953827","doi":"10.1007/s40263-018-0579-4","title":"From LBR-101 to Fremanezumab for Migraine","year":2018,"lang":"en","type":"review","venue":"CNS Drugs","topic":"Migraine and Headache Studies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Calcitonin gene-related peptide; Migraine; Chronic Migraine; Medicine; Calcitonin; Monoclonal antibody; Drug development; Pharmacology; In vivo; Receptor; Bioinformatics; Neuroscience; Antibody; Neuropeptide; Immunology; Drug; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001300744,0.0009840829,0.003358586,0.004801953,0.0002571035,0.001438635,0.001060945,0.001427477,0.01177114],"category_scores_gemma":[0.003218752,0.0004666857,0.002323621,0.003438851,0.0005501211,0.001261471,0.001028715,0.001589356,0.0009186377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007558449,"about_ca_system_score_gemma":0.00157156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001980177,"about_ca_topic_score_gemma":0.00809864,"domain_scores_codex":[0.9994557,0.0001621867,0.0001777213,0.00006680629,0.0001008075,0.00003668498],"domain_scores_gemma":[0.9987158,0.0008216166,0.0003017005,0.00002097306,0.00009828962,0.00004166403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009655473,0.0001081701,0.0003098997,0.3311763,0.003837025,0.0003152599,0.0001267636,0.0002291179,0.0009115984,0.001259058,0.0181486,0.6426127],"study_design_scores_gemma":[0.002312589,0.001302371,0.005365648,0.2443923,0.03394821,0.002824028,0.0003802861,0.0001797,0.0008863423,0.001878346,0.7064291,0.0001010098],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001343637,0.9992664,0.0000197219,0.0001041583,0.00008057112,0.000008664897,0.00003338525,0.000002586117,0.0003500788],"genre_scores_gemma":[0.002013256,0.9970741,0.0001153231,0.0003937711,0.0000973026,0.00001471607,0.00003694268,0.00000113149,0.0002535105],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01177114,"threshold_uncertainty_score":0.0393784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08518251319761845,"score_gpt":0.4039379044625236,"score_spread":0.3187553912649052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}