{"id":"W2895958365","doi":"10.1172/jci.insight.124642","title":"Glycine decarboxylase deficiency–induced motor dysfunction in zebrafish is rescued by counterbalancing glycine synaptic level","year":2018,"lang":"en","type":"article","venue":"JCI Insight","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; GDG Environnement; Université de Montréal","funders":"Medical Research Council","keywords":"Hyperglycinemia; Glycine; Zebrafish; Glycine cleavage system; Synapse; Biology; NMDA receptor; Amino acid; Chemistry; Biochemistry; Molecular biology; Gene; Receptor; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001946787,0.0002427039,0.0002487463,0.0001240762,0.0001171423,0.00002971091,0.0001815829,0.000342654,0.0002710282],"category_scores_gemma":[0.0001922721,0.0002248274,0.00008013891,0.0002556271,0.00008937362,0.00001206645,0.00008550976,0.0001753733,0.0001326799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005901506,"about_ca_system_score_gemma":0.00008634788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001463872,"about_ca_topic_score_gemma":0.0004482333,"domain_scores_codex":[0.9983433,0.0001028695,0.0003808504,0.0006115211,0.000181811,0.0003795942],"domain_scores_gemma":[0.9991142,0.0000205174,0.0001107503,0.0004790637,0.0001603687,0.0001151322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005358749,0.0001103944,0.001445289,0.00001336471,0.00002118527,0.00001165019,0.0001366216,0.000001555471,0.9780031,0.00004749577,0.01933236,0.0003410667],"study_design_scores_gemma":[0.003945228,0.00315649,0.004442707,0.00004740689,0.0000363207,0.00008747538,0.0001121451,0.000533615,0.7978903,0.0000468921,0.1891486,0.0005527865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899317,0.0003861643,0.002511733,0.0003336915,0.001663521,0.0002893267,0.0000506159,0.00003397385,0.004799242],"genre_scores_gemma":[0.9938606,0.00004886755,0.0002496407,0.00256345,0.0007617101,0.00003415136,0.0001550933,0.00003408025,0.002292404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1801128,"threshold_uncertainty_score":0.9168197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01990921009233112,"score_gpt":0.2495763603277208,"score_spread":0.2296671502353897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}