{"id":"W2895961390","doi":"10.1093/annonc/mdy279.399","title":"Initial results from a phase I/IIa trial evaluating BMS-986158, an inhibitor of the bromodomain and extra-terminal (BET) proteins, in patients (pts) with advanced cancer","year":2018,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Medicine; Bromodomain; Pharmacokinetics; Pharmacodynamics; Cancer; Internal medicine; Pharmacology; Mucositis; Gastroenterology; Toxicity; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001062228,0.0007908281,0.0009753513,0.0001977093,0.0002679668,0.0004702879,0.0002603708,0.0004772787,0.002967268],"category_scores_gemma":[0.0007547824,0.0002209522,0.0005186556,0.0003014978,0.0003776071,0.0004779698,0.0002268261,0.00162753,0.0007046688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004587209,"about_ca_system_score_gemma":0.0006383908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003971167,"about_ca_topic_score_gemma":0.001697697,"domain_scores_codex":[0.9998115,0.00007502995,0.00002061437,0.00003383632,0.00003226973,0.00002675489],"domain_scores_gemma":[0.9996332,0.0001159623,0.00006497333,0.00002215731,0.000034993,0.0001286576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2165936,0.03656481,0.03975044,0.001667065,0.001561371,0.001179931,0.0005774384,0.006114903,0.2564997,0.000733432,0.01775004,0.4210073],"study_design_scores_gemma":[0.1946786,0.6146595,0.1082629,0.0001668368,0.002373125,0.002258832,0.0001646063,0.003626574,0.04516692,0.0009912781,0.02758464,0.00006602344],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878963,0.002667813,0.001044662,0.0008153587,0.00006811821,0.001396386,0.001734736,0.00009121136,0.004285369],"genre_scores_gemma":[0.9849155,0.003103489,0.002353096,0.001034863,0.0001253118,0.0009056077,0.004516812,0.00003395761,0.003011403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002967268,"threshold_uncertainty_score":0.009926498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06594714153376163,"score_gpt":0.4142067863036477,"score_spread":0.3482596447698861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}