{"id":"W2895969689","doi":"10.1038/s41467-018-06854-2","title":"Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Sinai Health System; Université Laval; Université de Montréal; Hôpital Maisonneuve-Rosemont; Lunenfeld-Tanenbaum Research Institute","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Defense; Génome Québec; Canadian Institutes of Health Research; Genome Canada; Mesothelioma Applied Research Foundation; Fonds de Recherche du Québec - Santé; University of Hawaiʻi Foundation","keywords":"Deubiquitinating enzyme; Biology; BAP1; Ubiquitin; Cell biology; Suppressor; Transcription factor; Cancer research; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004346771,0.0001021706,0.0001290649,0.0000230602,0.0002661156,0.00001138149,0.001369497,0.0001719856,0.00001810951],"category_scores_gemma":[0.000641217,0.00006498848,0.0001234926,0.0001619956,0.0005917689,0.00000608146,0.0005522955,0.0003461781,0.000002527587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009410064,"about_ca_system_score_gemma":0.0001032513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002408214,"about_ca_topic_score_gemma":0.0002727671,"domain_scores_codex":[0.9990008,0.0003733702,0.0002055315,0.0001381533,0.0001503774,0.0001316947],"domain_scores_gemma":[0.9970932,0.0001521252,0.0002929517,0.002005698,0.0004286849,0.00002735687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005543894,0.0001201117,0.0009275113,0.00001269728,0.00003874551,3.952778e-8,0.0001398531,0.000001538537,0.9892724,0.007129113,0.001362913,0.0009396375],"study_design_scores_gemma":[0.0002851599,0.0001176755,0.0112531,0.00002268474,0.00002874284,0.000004656994,0.00005969427,0.0001299085,0.953971,0.0002803676,0.03377561,0.00007144835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984978,0.001679979,0.0001572993,0.003444892,0.0001207483,0.0005793082,0.0001836196,0.000009880388,0.008846247],"genre_scores_gemma":[0.9986004,0.00006243901,0.000547988,0.0004496722,0.0001060397,0.00006829714,0.0000340295,0.00001226202,0.0001188925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03530144,"threshold_uncertainty_score":0.2650153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01696362688430447,"score_gpt":0.2908989135571426,"score_spread":0.2739352866728382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}