{"id":"W2896152421","doi":"10.1016/j.str.2018.09.007","title":"Non-syndromic Mitral Valve Dysplasia Mutation Changes the Force Resilience and Interaction of Human Filamin A","year":2018,"lang":"en","type":"article","venue":"Structure","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Fédération Française de Cardiologie; Academy of Finland; Institut National de la Santé et de la Recherche Médicale; Petroleum Research Newfoundland and Labrador; National Institutes of Health; National Science Foundation","keywords":"FLNA; Filamin; Missense mutation; Mutation; Biology; Cell biology; Genetics; Cytoskeleton; Gene; Cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009942702,0.0002382901,0.0001279163,0.0001496659,0.0002092654,0.0002346004,0.0003323124,0.0003796315,0.002533089],"category_scores_gemma":[0.0002416707,0.0001163004,0.0001606313,0.00008096833,0.0002673051,0.0001591087,0.0002274297,0.0003588324,0.0004414313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002457637,"about_ca_system_score_gemma":0.0001506132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001029957,"about_ca_topic_score_gemma":0.0008976229,"domain_scores_codex":[0.9998981,0.00002233922,0.000007300171,0.00002108052,0.00003166468,0.00001951813],"domain_scores_gemma":[0.9998726,0.0000312148,0.00003509691,0.00001507363,0.00001195164,0.00003413731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002029617,0.0000253657,0.001480514,0.00002227463,0.00001947413,0.0006372683,0.00003201238,0.0002769787,0.9937488,0.0005560325,0.0001227305,0.002875645],"study_design_scores_gemma":[0.00003790368,0.000256087,0.02962617,0.00001976436,0.00005071473,0.004018019,0.0002119019,0.004822871,0.9548836,0.0007851995,0.005261987,0.00002568074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981555,0.000207676,0.0008128167,0.00007031752,0.00001820604,0.00000245422,0.00006423584,0.00001487831,0.0006538582],"genre_scores_gemma":[0.9990858,0.00005155137,0.000244682,0.00002101495,0.000002367617,0.00000102158,0.00003461877,0.000006310399,0.000552609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002533089,"threshold_uncertainty_score":0.008473992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008190064101256367,"score_gpt":0.2477858414909084,"score_spread":0.239595777389652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}