{"id":"W2896174696","doi":"10.1002/art.40748","title":"Annotating Transcriptional Effects of Genetic Variants in Disease‐Relevant Tissue: Transcriptome‐Wide Allelic Imbalance in Osteoarthritic Cartilage","year":2018,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Seventh Framework Programme; ZonMw; Universiteit Leiden; Leids Universitair Medisch Centrum; European Commission; Arthritis Society; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Dutch Arthritis Society","keywords":"Single-nucleotide polymorphism; Transcriptome; Biology; Allele; Genetics; Cartilage; SNP; Candidate gene; Gene; Osteoarthritis; False discovery rate; Bioinformatics; Gene expression; Genotype; Medicine; Pathology; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002195627,0.0004077688,0.0008716563,0.001718538,0.0003501526,0.0008446057,0.0004740813,0.0004389964,0.0008970214],"category_scores_gemma":[0.002169078,0.0002355828,0.001356963,0.002254536,0.0002939381,0.000267232,0.0004742011,0.0003619049,0.0001123501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001990903,"about_ca_system_score_gemma":0.0002296652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001034334,"about_ca_topic_score_gemma":0.002236563,"domain_scores_codex":[0.9986975,0.0003752621,0.0001323243,0.0005290518,0.0001906824,0.00007510347],"domain_scores_gemma":[0.9980931,0.001008808,0.0005363423,0.000191328,0.00008911065,0.00008133063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001410451,0.00006265358,0.8649669,0.0008167762,0.008547934,0.000473187,0.0001886852,0.002345116,0.09115598,0.0001174717,0.0004162763,0.0294985],"study_design_scores_gemma":[0.0000679535,0.0003130972,0.9770554,0.00007454411,0.006596564,0.000998279,0.0002090326,0.004431736,0.008517006,0.0003712389,0.001340428,0.0000247423],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874927,0.006184514,0.004495988,0.00009980261,0.00001885435,0.00001207072,0.001379993,0.00005791665,0.0002582124],"genre_scores_gemma":[0.9961703,0.0007997947,0.001954441,0.00005592785,0.00002011892,0.00001823747,0.0008266786,0.00001853208,0.0001360188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002195627,"threshold_uncertainty_score":0.0116117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006352926739011204,"score_gpt":0.2399932051145098,"score_spread":0.2336402783754986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}