{"id":"W2896175664","doi":"10.1016/s0140-6736(18)32483-8","title":"Efficacy and safety of filgotinib, a selective Janus kinase 1 inhibitor, in patients with active psoriatic arthritis (EQUATOR): results from a randomised, placebo-controlled, phase 2 trial","year":2018,"lang":"en","type":"article","venue":"The Lancet","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":204,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"Genentech; National Institute for Health and Care Research; Celltrion; Prothena; Gilead Sciences; Amgen; Pfizer; Celgene; AstraZeneca; Eli Lilly and Company; Sun Pharma; GlaxoSmithKline","keywords":"Psoriatic arthritis; Medicine; Placebo; Placebo-controlled study; Internal medicine; Pegfilgrastim; Randomized controlled trial; Arthritis; Pharmacology; Double blind; Chemotherapy; Neutropenia; Pathology; Alternative medicine; Filgrastim","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000331104,0.0002270036,0.001273905,0.00006713071,0.0001226751,0.00001360892,0.00007529835,0.00006913227,0.00002768021],"category_scores_gemma":[0.000992406,0.0001352323,0.0000722067,0.0002105679,0.0002285106,0.00006133164,0.00004316053,0.0001886049,0.000007887761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007624088,"about_ca_system_score_gemma":0.00008314325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004073625,"about_ca_topic_score_gemma":0.0004908729,"domain_scores_codex":[0.9983296,0.0002147632,0.0005124998,0.0003435145,0.0002884917,0.0003111298],"domain_scores_gemma":[0.9981946,0.0009291974,0.0002912563,0.0003562167,0.0001488662,0.00007990474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9664676,0.001268786,0.001352161,0.000007023079,0.0005972324,0.00002843362,0.00302413,5.847947e-7,0.00002023047,0.000007352129,0.0005108603,0.02671556],"study_design_scores_gemma":[0.9525393,0.00785903,0.03763235,0.0004878355,0.0002674037,0.000002362027,0.0001685954,0.00002313073,0.0005634328,0.00006307768,0.0002668228,0.0001266052],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924055,0.0004182035,0.000004064687,0.0003150471,0.0002179451,0.004732406,0.0006994421,0.00002178748,0.001185635],"genre_scores_gemma":[0.9981996,0.0001887804,0.0001384195,0.00009306801,0.00100801,0.0002133254,0.0001121714,0.00001924632,0.00002737969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03628019,"threshold_uncertainty_score":0.5514613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.012895451061264,"score_gpt":0.2668220078334789,"score_spread":0.2539265567722149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}