{"id":"W2896175664","doi":"10.1016/s0140-6736(18)32483-8","title":"Efficacy and safety of filgotinib, a selective Janus kinase 1 inhibitor, in patients with active psoriatic arthritis (EQUATOR): results from a randomised, placebo-controlled, phase 2 trial","year":2018,"lang":"en","type":"article","venue":"The Lancet","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":204,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"Genentech; National Institute for Health and Care Research; Celltrion; Prothena; Gilead Sciences; Amgen; Pfizer; Celgene; AstraZeneca; Eli Lilly and Company; Sun Pharma; GlaxoSmithKline","keywords":"Psoriatic arthritis; Medicine; Placebo; Placebo-controlled study; Internal medicine; Pegfilgrastim; Randomized controlled trial; Arthritis; Pharmacology; Double blind; Chemotherapy; Neutropenia; Pathology; Alternative medicine; Filgrastim","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003898093,0.001151907,0.002753366,0.0003572709,0.0004088257,0.001103264,0.0005191143,0.001490071,0.005459787],"category_scores_gemma":[0.003193635,0.0005593434,0.002298968,0.0003612691,0.0008642808,0.000950869,0.0003631735,0.001963489,0.0006965625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005589083,"about_ca_system_score_gemma":0.0008310652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004436505,"about_ca_topic_score_gemma":0.001264625,"domain_scores_codex":[0.9985695,0.0008428785,0.0001459121,0.0001963755,0.0001000867,0.0001452018],"domain_scores_gemma":[0.9985234,0.0004541258,0.0004112862,0.0001099415,0.000132113,0.0003691263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9764791,0.002485185,0.001137862,0.001202567,0.001348087,0.00004822906,0.00006584616,0.0001513022,0.00289717,0.00006642137,0.0007268696,0.01339129],"study_design_scores_gemma":[0.9603349,0.03532756,0.002710396,0.0000434251,0.0006657007,0.00004629411,0.00001554246,0.00009736093,0.0001748632,0.00005964485,0.0005154552,0.000008893692],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737827,0.01657032,0.0005254984,0.000831232,0.0004772203,0.003446958,0.001631716,0.00009272812,0.002641766],"genre_scores_gemma":[0.9840465,0.00662958,0.001220205,0.001259738,0.000574559,0.003040107,0.001535637,0.00001910986,0.001674607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005459787,"threshold_uncertainty_score":0.02061534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.012895451061264,"score_gpt":0.2668220078334789,"score_spread":0.2539265567722149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}