{"id":"W2896179149","doi":"10.1097/aci.0000000000000486","title":"Very early onset IBD: novel genetic aetiologies","year":2018,"lang":"en","type":"review","venue":"Current Opinion in Allergy and Clinical Immunology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Medicine; Penetrance; Inflammatory bowel disease; Disease; Mechanism (biology); Genome-wide association study; Crohn's disease; Etiology; Bioinformatics; Immunology; Intensive care medicine; Genetics; Phenotype; Gene; Pathology; Genotype; Biology; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004277687,0.0008310003,0.001310678,0.001556486,0.0002654747,0.0008719068,0.0007425782,0.001199978,0.004248491],"category_scores_gemma":[0.001255517,0.0001774469,0.000458373,0.001275855,0.0004601442,0.001132136,0.0006820868,0.001736095,0.001642953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004392507,"about_ca_system_score_gemma":0.001116817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006356233,"about_ca_topic_score_gemma":0.000760025,"domain_scores_codex":[0.9997965,0.00004116324,0.00003663356,0.00004218661,0.00005662884,0.00002704512],"domain_scores_gemma":[0.9994699,0.0002721435,0.0000978348,0.00001470899,0.00009858435,0.0000468906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001166865,0.00004349842,0.0009730908,0.02585368,0.0001689494,0.001756141,0.0001117453,0.0003803831,0.001183656,0.004516905,0.06530696,0.8995883],"study_design_scores_gemma":[0.00002047292,0.00006342984,0.002274825,0.01104022,0.0002549151,0.01551525,0.0001366013,0.00008426828,0.0003306327,0.003741537,0.9665112,0.00002655359],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001068021,0.9983659,0.0001033357,0.0004387965,0.0003266754,0.000002834618,0.00001582364,0.000007439023,0.0006323465],"genre_scores_gemma":[0.0009643129,0.9977618,0.0001231913,0.0002904241,0.000526095,0.000003206654,0.00003468217,0.000001765778,0.0002944265],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004248491,"threshold_uncertainty_score":0.01421267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09327451249245516,"score_gpt":0.4026373661026475,"score_spread":0.3093628536101923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}