{"id":"W2896212671","doi":"10.1093/jnci/djy132","title":"Height and Body Mass Index as Modifiers of Breast Cancer Risk in <i>BRCA1</i>/<i>2</i> Mutation Carriers: A Mendelian Randomization Study","year":2018,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Cancer Risks and Factors","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval; Centre hospitalier universitaire de Québec; Hôpital du Saint-Sacrement; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Jonsson Comprehensive Cancer Center; National Center for Advancing Translational Sciences; Instituto de Salud Carlos III; Medical Research Council; Cancer Center, University of Kansas; University of California, Los Angeles; National Institutes of Health; Kerry Group Kuok Foundation; Centro de Investigación Biomédica en Red de Cáncer; Universitätsklinikum Köln; lékařská fakulta Univerzity Karlovy; Newcastle upon Tyne Hospitals NHS Foundation Trust; Institut Català de la Salut; Institut Gustave-Roussy; Ministero dello Sviluppo Economico; Royal Marsden NHS Foundation Trust; Sahlgrenska Universitetssjukhuset; Fondazione Italiana per la Ricerca sul Cancro; Arcadia Fund; Uppsala Universitet; Hospices Civils de Lyon; National Health and Medical Research Council; Deutsche Krebshilfe; Pritzker School of Medicine; Medizinische Universität Wien; Universitair Medisch Centrum Groningen; University of Texas MD Anderson Cancer Center; Memorial Sloan-Kettering Cancer Center; Istituto Oncologico Veneto; Institut National Du Cancer; Leids Universitair Medisch Centrum; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Centre National de la Recherche Scientifique; Fox Chase Cancer Center; KWF Kankerbestrijding; Canadian Institutes of Health Research; European Commission; Cedars-Sinai Medical Center; Lietuvos Mokslo Taryba; Háskóli Íslands; Lombardi Comprehensive Cancer Center, Georgetown University; Landspítali Háskólasjúkrahús; Israel Cancer Association; Children's Hospital of Philadelphia; University of Hong Kong; Harvard T.H. Chan School of Public Health; Hungarian Scientific Research Fund; Huntsman Cancer Institute; Fonds Wetenschappelijk Onderzoek; University of Pretoria; Radboud Universitair Medisch Centrum; Universität Wien; Erasmus Medisch Centrum; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Gentofte Hospital; University of Toronto; Univerzita Karlova v Praze; McGill University; Generalitat de Catalunya; Soonchunhyang University; National Breast Cancer Foundation; National Cancer Institute; European Regional Development Fund; Peking University; Seoul National University; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Rigshospitalet; University of Melbourne; Rijksuniversiteit Groningen; Maastricht Universitair Medisch Centrum; Moffitt Cancer Center; Ohio State University; Universiteit Leiden; Ministerstvo Školství, Mládeže a Tělovýchovy; Liga Portuguesa Contra o Cancro; Helsingin Yliopisto; Hospital de Câncer de Barretos; Pomorski Uniwersytet Medyczny W Szczecinie; Vrije Universiteit Amsterdam; Seoul National University Bundang Hospital; Ministero della Salute; Institut National de la Santé et de la Recherche Médicale; Cancer Australia; Radboud Universiteit; Fundación Mutua Madrileña; Universität Ulm; Cancer Research UK; Associazione Italiana per la Ricerca sul Cancro; Beckman Research Institute, City of Hope; Wellcome Trust; Breast Cancer Research Foundation; Unicancer; Clalit Health Services; Deutsches Krebsforschungszentrum; Jewish General Hospital; National Institute for Health and Care Research; University of Kansas; Freistaat Sachsen; Kansas Bioscience Authority; University of Chicago; NorthShore University HealthSystem; Cancer Research Institute; University Hospitals of Leicester NHS Trust; NRG Oncology; Tel Aviv University; Universiteit Maastricht; Fundación Cellex; Fisher Center for Alzheimer's Research Foundation; School of Medicine; QIMR Berghofer Medical Research Institute; National Institute on Handicapped Research; Georgetown University","keywords":"Mendelian randomization; Breast cancer; Body mass index; Oncology; Mendelian inheritance; Mutation; Medicine; Index (typography); Randomization; Internal medicine; Cancer; Genetics; Biology; Clinical trial; Gene; Genotype; Computer science; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006312982,0.0001434409,0.0003712249,0.0002939506,0.0001192402,0.00002245564,0.0001344921,0.00007526558,0.00009001293],"category_scores_gemma":[0.0001828357,0.00009636685,0.0001099595,0.0004965682,0.0002095838,0.0003775595,0.00002632126,0.0003095738,5.518445e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006485301,"about_ca_system_score_gemma":0.00118935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004789767,"about_ca_topic_score_gemma":0.003034559,"domain_scores_codex":[0.9980865,0.0000918072,0.0006127086,0.0001605254,0.0009087116,0.0001397103],"domain_scores_gemma":[0.9979227,0.00004134043,0.0007433991,0.0000956168,0.001091765,0.0001052451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01298301,0.0004265593,0.9412476,0.00008903896,0.001113479,0.00002726937,0.004831923,0.0215342,0.005126056,0.0002101013,0.002257071,0.01015372],"study_design_scores_gemma":[0.03403921,0.0005729039,0.950153,0.0005820045,0.0006335577,0.0002499356,0.001027386,0.004557564,0.003258885,0.00129757,0.003381416,0.0002465928],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954231,0.0004977553,0.0002653488,0.001277677,0.001430061,0.0005223817,0.00016496,0.000004750337,0.0004139237],"genre_scores_gemma":[0.9979311,0.0006417964,0.00005833936,0.0003646675,0.0008854455,0.00002482848,0.000002706989,0.00001351222,0.00007761094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0210562,"threshold_uncertainty_score":0.7240727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02078430405465525,"score_gpt":0.3308104170208688,"score_spread":0.3100261129662136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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