{"id":"W2896214663","doi":"10.1021/acs.orglett.8b02703","title":"<i>N</i>-Silylenamines as Reactive Intermediates: Hydroamination for the Modular Synthesis of Selectively Substituted Pyridines","year":2018,"lang":"en","type":"article","venue":"Organic Letters","topic":"Advanced Synthetic Organic Chemistry","field":"Chemistry","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Deutscher Akademischer Austauschdienst","keywords":"Hydroamination; Chemistry; Regioselectivity; Combinatorial chemistry; Catalysis; Organic chemistry; Medicinal chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000199577,0.0005712022,0.0001929238,0.0001471034,0.0001334087,0.0001937395,0.0005687493,0.000259358,0.001447721],"category_scores_gemma":[0.0001748177,0.0002522336,0.0002865386,0.0001160687,0.0002467922,0.0003891308,0.0004149297,0.0005609839,0.0008890023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002877536,"about_ca_system_score_gemma":0.0002656309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003574812,"about_ca_topic_score_gemma":0.0009246265,"domain_scores_codex":[0.9998858,0.00001394304,0.00000962582,0.00002784803,0.00003284315,0.00002984012],"domain_scores_gemma":[0.9999126,0.00001369115,0.00002996546,0.00001669148,0.00001086622,0.0000161994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006151071,0.00002487386,0.00008472714,0.0001297735,0.000009837968,0.000267509,0.00005618385,0.0004613171,0.990729,0.0009717044,0.0001270324,0.007076541],"study_design_scores_gemma":[0.00001028226,0.0001676542,0.000257129,0.000006320208,0.000008126266,0.0002858819,0.00001048408,0.0004550258,0.9949958,0.00009625837,0.003699483,0.000007434572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9034709,0.004077835,0.06989252,0.0002266699,0.0001275713,0.0002519096,0.0006416493,0.0007380432,0.02057307],"genre_scores_gemma":[0.9702917,0.002747892,0.02168096,0.00007554851,0.00002466437,0.000103213,0.000300048,0.00007780267,0.004698225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001447721,"threshold_uncertainty_score":0.004843056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006561779759489578,"score_gpt":0.2255410030413812,"score_spread":0.2189792232818916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}