{"id":"W2896220657","doi":"10.1186/s12575-018-0085-6","title":"Three-Dimensional Quantification of Spheroid Degradation-Dependent Invasion and Invadopodia Formation","year":2018,"lang":"en","type":"article","venue":"Biological Procedures Online","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto","funders":"Faculty of Dentistry, University of Toronto; Canadian Cancer Society Research Institute; University of Toronto","keywords":"Invadopodia; Spheroid; Cell biology; Matrix (chemical analysis); Matrix metalloproteinase; Basement membrane; Tumor microenvironment; Cancer cell; In vitro; Cell; Biophysics; Cancer; Chemistry; Biology; Cancer research; Tumor cells; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007158138,0.0006191458,0.0004227905,0.00124969,0.0004949864,0.0005210956,0.000279138,0.0006219631,0.001211403],"category_scores_gemma":[0.0004536849,0.0002771349,0.0004019283,0.0009501894,0.0004535708,0.0003726285,0.000422351,0.001041937,0.0004029596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005424845,"about_ca_system_score_gemma":0.0004449223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001490173,"about_ca_topic_score_gemma":0.002612751,"domain_scores_codex":[0.9992855,0.0001264575,0.0000771159,0.0001067154,0.0003403589,0.00006393529],"domain_scores_gemma":[0.9993117,0.0002400259,0.0001221208,0.00008072722,0.000155032,0.00009050535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003466592,0.00003587907,0.0005277349,0.00007481565,0.00001008857,0.00003350356,0.0001009484,0.0003678645,0.9963742,0.0003214265,0.00008344156,0.002035403],"study_design_scores_gemma":[0.000007295866,0.0000694925,0.01072173,0.000009708381,0.00002215565,0.0001840177,0.00005749424,0.01277984,0.9738981,0.0002065737,0.002021676,0.0000218132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7511057,0.003848805,0.2339518,0.0001773642,0.0001039157,0.0003536373,0.003183267,0.001219577,0.006055843],"genre_scores_gemma":[0.7593152,0.003612872,0.2268025,0.0001095526,0.00002686188,0.0009344523,0.003599544,0.0002317038,0.005367398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001490173,"threshold_uncertainty_score":0.004052579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03914196205886246,"score_gpt":0.2780818538295296,"score_spread":0.2389398917706672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}