{"id":"W2896243600","doi":"10.1038/s41467-018-06742-9","title":"Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Malaria Research and Control","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"National Research Council Canada; Western Economic Diversification Canada; Canadian Institutes of Health Research; Canada Research Chairs; National Institutes of Health; University of Saskatchewan; Canadian Light Source; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Bill and Melinda Gates Foundation","keywords":"Epitope; Gametocyte; Plasmodium falciparum; Monoclonal antibody; Biology; Virology; Malaria; Antigen; Anopheles; Antibody; Malaria vaccine; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001048019,0.0001661043,0.000113573,0.00006050317,0.00009139528,0.0001348875,0.0001519407,0.0001486248,0.0005270342],"category_scores_gemma":[0.00009031311,0.00006793059,0.0001660166,0.00003879003,0.0001136064,0.0001439414,0.0001065104,0.0003813177,0.0001651407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001922839,"about_ca_system_score_gemma":0.0001570226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004791449,"about_ca_topic_score_gemma":0.0004477092,"domain_scores_codex":[0.9999628,0.000007592727,0.000002363959,0.000005316941,0.000008073311,0.00001381433],"domain_scores_gemma":[0.9999676,0.000005933383,0.000008587621,0.000003160894,0.000004506662,0.00001017322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000109374,0.00003712572,0.0002515474,0.00001813722,0.000003276607,0.0000658112,0.00001723197,0.000577899,0.9971697,0.0002766945,0.00004240723,0.00143074],"study_design_scores_gemma":[0.00005508823,0.0009077868,0.003538465,0.00001026096,0.00002296215,0.0004639529,0.0000377613,0.004198813,0.9876368,0.0001412971,0.002979557,0.000007199967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961107,0.000282056,0.002440756,0.00004814203,0.000007957488,0.00001868711,0.00004874678,0.00001903748,0.001023901],"genre_scores_gemma":[0.9970213,0.0002535887,0.002180431,0.00004879925,0.000004178145,0.000007032693,0.0001212543,0.000004991132,0.000358489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005270342,"threshold_uncertainty_score":0.001763046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02834586864405702,"score_gpt":0.3488250550547523,"score_spread":0.3204791864106952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}