{"id":"W2896293784","doi":"10.1111/epi.14576","title":"γ‐Aminobutyric acid receptor alpha 1 subunit loss of function causes genetic generalized epilepsy by impairing inhibitory network neurodevelopment","year":2018,"lang":"en","type":"article","venue":"Epilepsia","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"British American Tobacco (Canada); Espace pour la vie; Université de Montréal; GDG Environnement","funders":"Dravet Canada; Savoy Foundation; National Institutes of Health; Mylan","keywords":"Epileptogenesis; GABAergic; Neuroscience; Epilepsy; Inhibitory postsynaptic potential; Biology; Zebrafish; GABAA receptor; Receptor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007805667,0.0009791245,0.0002505472,0.0004625312,0.0001339402,0.0001965888,0.0001699816,0.0002562157,0.001222991],"category_scores_gemma":[0.0001330737,0.0001578296,0.0002480448,0.0001428512,0.0004332821,0.0001062724,0.0002585383,0.0003235105,0.0003170526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000248952,"about_ca_system_score_gemma":0.000230485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009304468,"about_ca_topic_score_gemma":0.002527416,"domain_scores_codex":[0.9998745,0.00001186398,0.00001496263,0.00003683373,0.0000412733,0.0000205605],"domain_scores_gemma":[0.999893,0.00001358963,0.000062389,0.000008276901,0.000006282962,0.00001646253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003572717,0.000009246807,0.0004555236,0.0000455964,0.00000844437,0.0003086789,0.000008365274,0.00008910961,0.9978034,0.00005759651,0.00004634957,0.001131977],"study_design_scores_gemma":[0.00004155791,0.0004092814,0.05037533,0.00005254665,0.0001560575,0.004432781,0.0001230469,0.001929923,0.9382225,0.0002281221,0.004011339,0.00001749614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925392,0.001490557,0.003576132,0.0001383413,0.00002901424,0.00003587956,0.0008460782,0.0002475152,0.001097332],"genre_scores_gemma":[0.9935062,0.001305239,0.002416622,0.00007604388,0.000008372716,0.00004270515,0.0006487747,0.00005395065,0.00194206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001222991,"threshold_uncertainty_score":0.004091322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03512170404798771,"score_gpt":0.2949368188928228,"score_spread":0.2598151148448351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}