{"id":"W2896293784","doi":"10.1111/epi.14576","title":"γ‐Aminobutyric acid receptor alpha 1 subunit loss of function causes genetic generalized epilepsy by impairing inhibitory network neurodevelopment","year":2018,"lang":"en","type":"article","venue":"Epilepsia","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"British American Tobacco (Canada); Espace pour la vie; Université de Montréal; GDG Environnement","funders":"Dravet Canada; Savoy Foundation; National Institutes of Health; Mylan","keywords":"Epileptogenesis; GABAergic; Neuroscience; Epilepsy; Inhibitory postsynaptic potential; Biology; Zebrafish; GABAA receptor; Receptor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005137102,0.0003750323,0.0004164515,0.0002537991,0.0006255062,0.00007166441,0.0007665859,0.0001344187,0.0008853146],"category_scores_gemma":[0.0003728361,0.0003593197,0.0001248834,0.001380209,0.001123803,0.0003464905,0.0003887174,0.000469521,0.0005857323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007297521,"about_ca_system_score_gemma":0.0002037708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001302952,"about_ca_topic_score_gemma":0.00000266365,"domain_scores_codex":[0.9954446,0.0008740548,0.0006785465,0.001099904,0.0007937119,0.001109159],"domain_scores_gemma":[0.9983639,0.0003236776,0.000291193,0.0005468824,0.0001551192,0.0003192206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002890494,0.0001514853,0.01989604,0.00002283146,0.000007808888,0.00005388806,0.0001157456,0.00004697324,0.9338682,0.00005075506,0.04431863,0.001178637],"study_design_scores_gemma":[0.00083854,0.0009624269,0.02518293,0.00002335348,0.00002327663,0.00005546489,0.000008769986,0.0004339778,0.9474274,0.00006174559,0.02465049,0.0003316578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950594,0.0001956677,0.0003039905,0.000292556,0.003128571,0.000534702,0.00003018246,0.0001684592,0.0002864207],"genre_scores_gemma":[0.9944907,0.000664625,0.0001901991,0.002470074,0.0007540166,0.00007982686,0.000003968943,0.0000690579,0.001277469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01966814,"threshold_uncertainty_score":0.9998859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03512170404798771,"score_gpt":0.2949368188928228,"score_spread":0.2598151148448351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}