{"id":"W2896326574","doi":"10.1101/446229","title":"PACS-1 and Adaptor Protein-1 Mediate ACTH Trafficking to the Regulated Secretory Pathway","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Universities Space Research Association","keywords":"Cell biology; Signal transducing adaptor protein; Secretion; Secretory protein; Secretory pathway; Proprotein Convertases; Gene knockdown; Clathrin; Biology; Enteroendocrine cell; Protein targeting; Hormone; Cell; Endocytosis; Membrane protein; Signal transduction; Endocrine system; Endoplasmic reticulum; Gene; Golgi apparatus; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001429043,0.0002555104,0.0002085392,0.000185688,0.0002930815,0.0005227193,0.0003073048,0.0004089384,0.001843351],"category_scores_gemma":[0.0002165323,0.0001392966,0.0002696488,0.00009363359,0.0002465523,0.0004280121,0.0004462875,0.0007482526,0.001138109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005068961,"about_ca_system_score_gemma":0.0003048103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005825607,"about_ca_topic_score_gemma":0.0003961067,"domain_scores_codex":[0.999881,0.00001436563,0.00001083576,0.0000241771,0.000032135,0.00003735234],"domain_scores_gemma":[0.9998747,0.0000205283,0.00002575817,0.00002101735,0.00002155392,0.00003642353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009097166,0.00001249953,0.0003908124,0.00004122084,0.000004868997,0.0002243053,0.00002021206,0.00006498599,0.9975841,0.0006468889,0.000134305,0.0007847204],"study_design_scores_gemma":[0.00002873035,0.00004704617,0.007811153,0.00001080536,0.00001132769,0.0005626369,0.00006217301,0.001991327,0.9850481,0.0003434347,0.004076638,0.000006775098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911523,0.001714253,0.003258349,0.0003305653,0.0001001786,0.00002480531,0.0003600201,0.00007503301,0.00298441],"genre_scores_gemma":[0.9924484,0.000524926,0.001804875,0.00005466407,0.00001890814,0.00002480323,0.000514361,0.00002264651,0.004586313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001843351,"threshold_uncertainty_score":0.006166637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009119530029700035,"score_gpt":0.1928800397464613,"score_spread":0.1837605097167613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}