{"id":"W2896360542","doi":"10.1158/1538-7445.pedca17-b44","title":"Abstract B44: Identification of epigenomic changes induced by H3 K27M mutation in glioblastoma using patient-derived and CRISPR/Cas9 edited cell lines","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Chromatin immunoprecipitation; Histone H3; Epigenomics; Histone; Biology; H3K4me3; Chromatin; Epigenetics; Genetics; Methylation; Histone methylation; DNA methylation; Cancer research; Molecular biology; Gene expression; Gene; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003018219,0.0003299844,0.0003476479,0.0004991576,0.0002967123,0.0003198659,0.0002868527,0.0004033614,0.003509453],"category_scores_gemma":[0.0002244515,0.0001926899,0.0003789647,0.0004286352,0.0001963279,0.0001070213,0.0002816087,0.0007479485,0.00122674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002918571,"about_ca_system_score_gemma":0.0003326924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003339336,"about_ca_topic_score_gemma":0.003776068,"domain_scores_codex":[0.999732,0.00002220104,0.00003516665,0.00007464416,0.00009034511,0.00004571548],"domain_scores_gemma":[0.9998491,0.00002071167,0.00002358562,0.00002594884,0.00003973829,0.00004095396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001810948,0.00006798207,0.002132369,0.00007393763,0.00002730417,0.0002191452,0.00005832899,0.0002213924,0.9921455,0.0001230184,0.0008700412,0.003879808],"study_design_scores_gemma":[0.00007265291,0.0006294482,0.04123776,0.00002566215,0.0001110528,0.001985929,0.0001266196,0.003874419,0.9382049,0.0002025943,0.0134895,0.00003945936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9536273,0.001043564,0.01910298,0.0003167708,0.0001549467,0.000282807,0.02181056,0.0008447185,0.002816338],"genre_scores_gemma":[0.946061,0.0009415186,0.01675187,0.0003496747,0.00001599227,0.0004286255,0.0287114,0.0002542353,0.006485763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003509453,"threshold_uncertainty_score":0.01174033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03484336375706161,"score_gpt":0.3928789856849013,"score_spread":0.3580356219278397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}