{"id":"W2896395792","doi":"10.1021/acschembio.8b00739","title":"Structural Insight into a Novel Formyltransferase and Evolution to a Nonribosomal Peptide Synthetase Tailoring Domain","year":2018,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Genomics and Phylogenetic Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; McGill University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Nonribosomal peptide; Formylation; Gene cluster; Biology; Adenylylation; Biochemistry; Gene; Gramicidin S; Polyketide synthase; Biosynthesis; Chemistry; Stereochemistry; Gramicidin; Polyketide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006557304,0.0002469033,0.0001530544,0.00009943214,0.0001609202,0.0003019779,0.0002481094,0.000407537,0.0008639914],"category_scores_gemma":[0.0000899059,0.0001304456,0.0001655347,0.0001749811,0.0002006503,0.0003737714,0.0001560056,0.0004844643,0.000246192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002797201,"about_ca_system_score_gemma":0.0003719905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007766111,"about_ca_topic_score_gemma":0.0006647111,"domain_scores_codex":[0.9999763,0.000003327254,0.000001950649,0.0000067622,0.000006045709,0.000005605515],"domain_scores_gemma":[0.9999729,0.000004543224,0.000005599373,0.000005148683,0.000003677079,0.000008035723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001411778,0.00006196577,0.001888955,0.0000580344,0.00001148686,0.0007677791,0.00007588852,0.002776192,0.9870697,0.002028291,0.00007085349,0.005049604],"study_design_scores_gemma":[0.00009872418,0.00111103,0.02576047,0.00002386793,0.00009353125,0.003250921,0.0005597609,0.02471412,0.9139643,0.003320439,0.02705594,0.00004687236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948794,0.0003054124,0.003225813,0.00008908884,0.000008543393,0.000009259114,0.00008919935,0.00004346255,0.001349844],"genre_scores_gemma":[0.9912321,0.0004586856,0.006354983,0.0000362879,0.000004780991,0.000006926513,0.0003362535,0.00001055964,0.001559401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008639914,"threshold_uncertainty_score":0.002890348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009939091913668645,"score_gpt":0.2377019409129788,"score_spread":0.2277628489993102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}