{"id":"W2896395792","doi":"10.1021/acschembio.8b00739","title":"Structural Insight into a Novel Formyltransferase and Evolution to a Nonribosomal Peptide Synthetase Tailoring Domain","year":2018,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Genomics and Phylogenetic Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; McGill University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Nonribosomal peptide; Formylation; Gene cluster; Biology; Adenylylation; Biochemistry; Gene; Gramicidin S; Polyketide synthase; Biosynthesis; Chemistry; Stereochemistry; Gramicidin; Polyketide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008041417,0.000191445,0.0001880035,0.00003832142,0.0001199118,0.00001226589,0.0001568645,0.0001811522,0.000006281202],"category_scores_gemma":[0.00009435624,0.0001656278,0.00005042505,0.00007364982,0.0002949729,0.000001431126,0.0002555816,0.00007361481,0.000008378789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002210051,"about_ca_system_score_gemma":0.00002926233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007768214,"about_ca_topic_score_gemma":0.00006692784,"domain_scores_codex":[0.9989558,0.00002124278,0.0001970198,0.000458278,0.0000452632,0.0003224223],"domain_scores_gemma":[0.9995018,0.00002168148,0.0000323704,0.0002293465,0.00007680105,0.00013797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001703376,0.00001606917,0.004738035,0.000007527545,0.00005412411,6.442813e-7,0.0003016951,6.523371e-7,0.9924557,0.0009062275,0.00005229032,0.001296727],"study_design_scores_gemma":[0.0007616432,0.0006184867,0.004142934,0.000008611914,0.00002131573,0.00004336741,0.00009117139,0.0000136632,0.9754552,0.001470995,0.01705175,0.0003208404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969918,0.0005401157,0.001480855,0.0003081993,0.0001347573,0.0001296805,0.00004950824,0.000006457855,0.0003586143],"genre_scores_gemma":[0.993781,0.00003526394,0.00517487,0.0003974942,0.0004941113,0.00003178753,0.00005185953,0.00001572003,0.00001784436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01700045,"threshold_uncertainty_score":0.6754104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009939091913668645,"score_gpt":0.2377019409129788,"score_spread":0.2277628489993102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}