{"id":"W2896471204","doi":"10.1016/j.jconrel.2018.10.018","title":"Tumor targeted genome editing mediated by a multi-functional gene vector for regulating cell behaviors","year":2018,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Natural Science Foundation of China; Canadian Celiac Association","keywords":"Genome editing; CRISPR; Biology; Cas9; Gene delivery; Cell biology; Gene; Molecular biology; Genetic enhancement; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003732429,0.0001703066,0.0003318531,0.00007645375,0.0001117355,0.00002390216,0.0001279837,0.0001036948,0.00004320246],"category_scores_gemma":[0.0005642434,0.0001461229,0.0002763927,0.00006647492,0.00004393729,0.000006131369,0.00002576369,0.0001280652,0.000002789035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000247467,"about_ca_system_score_gemma":0.0001118391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002429513,"about_ca_topic_score_gemma":0.000004071763,"domain_scores_codex":[0.9987679,0.00004211754,0.000558959,0.000179229,0.0001864743,0.0002653693],"domain_scores_gemma":[0.9987293,0.00004500276,0.0004190411,0.0001329813,0.0004940678,0.0001796309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00113805,0.00009643591,0.0001359876,0.00001218574,0.00009933424,0.000005850448,0.00002741746,0.00083494,0.9953223,6.584312e-7,0.002176294,0.0001505724],"study_design_scores_gemma":[0.03093049,0.00158208,0.002099851,0.00002971349,0.0002735398,0.0001150587,0.0001199798,0.01151304,0.9395826,0.000005988117,0.01338696,0.0003607102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8717449,0.002752686,0.1242929,0.00010487,0.0006812593,0.0003294597,0.0000590305,0.000009167633,0.00002575887],"genre_scores_gemma":[0.9908534,0.00002806352,0.006110324,0.0001322389,0.002375179,0.00002157719,0.00007699658,0.00003598274,0.0003662403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1191085,"threshold_uncertainty_score":0.5958717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005553121742923587,"score_gpt":0.2538061428772771,"score_spread":0.2482530211343535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}