{"id":"W2896479296","doi":"10.1016/j.celrep.2018.09.056","title":"Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; University Health Network; Princess Margaret Cancer Centre; Hospital for Sick Children; Ontario Institute for Cancer Research","funders":"National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Ontario Institute for Cancer Research; Terry Fox Foundation; Government of Ontario; Susan G. Komen; Breast Cancer Research Foundation","keywords":"CDH1; Immune system; Breast cancer; Invasive lobular carcinoma; Cancer research; Lobular carcinoma; Breast carcinoma; Biology; Mutation; Medicine; Immunology; Genetics; Cadherin; Gene; Cancer; Invasive ductal carcinoma; Ductal carcinoma","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001354894,0.00009148818,0.0001804663,0.00004571631,0.00008893105,0.000009723542,0.00003861129,0.00005865114,0.0002458854],"category_scores_gemma":[0.00003653861,0.0000642003,0.00004914344,0.0002358566,0.00009419278,0.00002801972,0.00004592761,0.00008895428,0.000008659014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002975648,"about_ca_system_score_gemma":0.0002334922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002880474,"about_ca_topic_score_gemma":0.00004171839,"domain_scores_codex":[0.9992234,0.00001895918,0.0003010654,0.0001954888,0.0001374039,0.0001237561],"domain_scores_gemma":[0.9991094,0.00001414999,0.0001554499,0.000392049,0.0002380297,0.00009090278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007212814,0.00009977276,0.015497,0.00005370128,0.00005746347,0.0003420315,0.002926237,0.000008076368,0.978475,0.0001972063,0.0005719042,0.001699521],"study_design_scores_gemma":[0.0006934336,0.000371295,0.109866,0.0001534216,0.00009116783,0.002462355,0.0002995373,0.0000176518,0.8832543,0.0004850838,0.002187258,0.000118523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946265,0.000364904,0.00003152816,0.0005334717,0.0003653944,0.000418778,0.000005077316,0.00001332332,0.003641029],"genre_scores_gemma":[0.997376,0.00001809703,0.0000883646,0.0003023366,0.00006214261,0.00001150501,0.000006947443,0.00001692136,0.002117676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09522069,"threshold_uncertainty_score":0.2692273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009346074774385864,"score_gpt":0.2314113941860571,"score_spread":0.2220653194116712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}