{"id":"W2896479296","doi":"10.1016/j.celrep.2018.09.056","title":"Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; University Health Network; Princess Margaret Cancer Centre; Hospital for Sick Children; Ontario Institute for Cancer Research","funders":"National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Ontario Institute for Cancer Research; Terry Fox Foundation; Government of Ontario; Susan G. Komen; Breast Cancer Research Foundation","keywords":"CDH1; Immune system; Breast cancer; Invasive lobular carcinoma; Cancer research; Lobular carcinoma; Breast carcinoma; Biology; Mutation; Medicine; Immunology; Genetics; Cadherin; Gene; Cancer; Invasive ductal carcinoma; Ductal carcinoma","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001689937,0.000390424,0.0003120691,0.0005553642,0.0001812348,0.0002828244,0.0001727051,0.0002899623,0.001257926],"category_scores_gemma":[0.0001557453,0.0002445049,0.0002574582,0.000238887,0.0003021634,0.0001320469,0.0004570274,0.0006650859,0.0003542029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003818719,"about_ca_system_score_gemma":0.0002559552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006216789,"about_ca_topic_score_gemma":0.001192295,"domain_scores_codex":[0.9997368,0.00003417241,0.00002210916,0.00003355901,0.00007228885,0.0001008589],"domain_scores_gemma":[0.9997855,0.00003944358,0.00005204963,0.00003595957,0.000008731396,0.00007837757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002699946,0.0001683083,0.00147243,0.00002230277,0.000009926085,0.0004363708,0.0000214804,0.0001199101,0.9957295,0.0001384433,0.00008289677,0.00152828],"study_design_scores_gemma":[0.0001436271,0.001375911,0.0432712,0.000005603848,0.00004738957,0.003627699,0.00008604654,0.001941668,0.9470024,0.0001504562,0.002337091,0.00001096799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982039,0.0002491275,0.0003004739,0.00003647183,0.000008859476,0.00002587148,0.0001031336,0.00005697354,0.001015314],"genre_scores_gemma":[0.9980215,0.0001299305,0.0003491299,0.00002954008,0.000005082615,0.0000250979,0.0001807352,0.00001187197,0.001247041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001257926,"threshold_uncertainty_score":0.004208207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009346074774385864,"score_gpt":0.2314113941860571,"score_spread":0.2220653194116712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}