{"id":"W2896513955","doi":"10.1038/s41467-018-06607-1","title":"The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":283,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Dental and Craniofacial Research; Leibniz-Gemeinschaft; Biotechnology and Biological Sciences Research Council; National Institute of Allergy and Infectious Diseases; Alexander von Humboldt-Stiftung; Medical Research Council; Directorate for Biological Sciences; National Institutes of Health; FP7 People: Marie-Curie Actions; King's Health Partners; European Commission; Rosetrees Trust; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Deutsche Forschungsgemeinschaft; King's College London; NHLBI Division of Intramural Research; European Molecular Biology Organization","keywords":"Pyroptosis; Inflammasome; Cytolysis; Candida albicans; Microbiology; Biology; Caspase 1; Macrophage; Cell biology; Immune system; Immunology; Inflammation; Cytotoxicity; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001270035,0.0002543947,0.0001654362,0.0002060772,0.0001330715,0.0002656073,0.000111564,0.0003814502,0.001030875],"category_scores_gemma":[0.0001424514,0.00008307266,0.0002395137,0.0001753758,0.0002613438,0.0001902458,0.0002785855,0.0005938814,0.0003011907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002517774,"about_ca_system_score_gemma":0.0001771796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000244751,"about_ca_topic_score_gemma":0.0002121781,"domain_scores_codex":[0.9998618,0.00002372869,0.00001448521,0.00002958377,0.00004076413,0.00002958411],"domain_scores_gemma":[0.9999232,0.00001155893,0.00002925016,0.000008166549,0.00000800528,0.00001987584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000155794,0.0000189719,0.0004784719,0.00004133707,0.000005441027,0.0003292966,0.00001248061,0.00003859559,0.9970425,0.0001347923,0.00009517455,0.001647121],"study_design_scores_gemma":[0.00003328315,0.0002147978,0.01581227,0.00001136269,0.00001319596,0.003590329,0.00003787583,0.0006144795,0.9772608,0.0002837603,0.002122186,0.000005721668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894543,0.004484395,0.003523855,0.0004015654,0.00005722667,0.00002015261,0.0003747864,0.0001101467,0.001573633],"genre_scores_gemma":[0.9958442,0.001508844,0.001187479,0.0001182371,0.00001359006,0.00001460155,0.000219924,0.000009206183,0.001084119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001030875,"threshold_uncertainty_score":0.003448606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007085414735508074,"score_gpt":0.2638796188738753,"score_spread":0.2567942041383673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}