{"id":"W2896513955","doi":"10.1038/s41467-018-06607-1","title":"The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":283,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Dental and Craniofacial Research; Leibniz-Gemeinschaft; Biotechnology and Biological Sciences Research Council; National Institute of Allergy and Infectious Diseases; Alexander von Humboldt-Stiftung; Medical Research Council; Directorate for Biological Sciences; National Institutes of Health; FP7 People: Marie-Curie Actions; King's Health Partners; European Commission; Rosetrees Trust; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Deutsche Forschungsgemeinschaft; King's College London; NHLBI Division of Intramural Research; European Molecular Biology Organization","keywords":"Pyroptosis; Inflammasome; Cytolysis; Candida albicans; Microbiology; Biology; Caspase 1; Macrophage; Cell biology; Immune system; Immunology; Inflammation; Cytotoxicity; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002884512,0.0001304214,0.0001027371,0.00004359608,0.0007897979,0.0000842293,0.0008719475,0.0001924998,0.000006307477],"category_scores_gemma":[0.000304275,0.00008314191,0.00005996542,0.0002208534,0.0005759072,0.00001195169,0.0004853019,0.0004526837,0.000008973215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001619935,"about_ca_system_score_gemma":0.00005853144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001148204,"about_ca_topic_score_gemma":0.009000409,"domain_scores_codex":[0.9991607,0.0001805287,0.0001884309,0.0001726548,0.00008564116,0.0002120613],"domain_scores_gemma":[0.9982123,0.0001615575,0.00008184866,0.001403023,0.0001137203,0.00002751591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003044493,0.0001743797,0.05818509,0.00001050919,0.0004773987,0.000001943458,0.002335022,0.00002392948,0.906239,0.005539746,0.01274516,0.01396332],"study_design_scores_gemma":[0.0007731218,0.0001594244,0.1109095,0.00002223343,0.0000685064,0.00001759035,0.002904378,0.0002340535,0.2456161,0.0004294841,0.6385122,0.0003534708],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755764,0.01582395,0.000004538484,0.006264168,0.0000583998,0.0001880815,0.000008578777,0.00001196073,0.002063947],"genre_scores_gemma":[0.9931034,0.005709759,0.0001707037,0.000429808,0.00009406883,0.0000472395,0.00004586052,0.00001659717,0.0003825518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.660623,"threshold_uncertainty_score":0.6074567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007085414735508074,"score_gpt":0.2638796188738753,"score_spread":0.2567942041383673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}