{"id":"W2896552337","doi":"10.1002/art.40753","title":"Efficacy and Safety of Ixekizumab in the Treatment of Radiographic Axial Spondyloarthritis: Sixteen‐Week Results From a Phase <scp>III</scp> Randomized, Double‐Blind, Placebo‐Controlled Trial in Patients With Prior Inadequate Response to or Intolerance of Tumor Necrosis Factor Inhibitors","year":2018,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":233,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Pfizer; National Center for Advancing Translational Sciences; Eli Lilly and Company","keywords":"Ixekizumab; Medicine; Placebo; Randomized controlled trial; Internal medicine; Clinical endpoint; Physical therapy; Disease; Secukinumab; Pathology; Psoriatic arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002679661,0.001147161,0.002344813,0.0002822124,0.0003584751,0.0008367216,0.0006891832,0.001341035,0.003782111],"category_scores_gemma":[0.001636999,0.0005821253,0.001385576,0.0002630303,0.0008912027,0.0007270922,0.0002924727,0.002080195,0.0005642381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000412506,"about_ca_system_score_gemma":0.0008188233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003715462,"about_ca_topic_score_gemma":0.0006785257,"domain_scores_codex":[0.9993176,0.0003742845,0.00007936722,0.00009004829,0.00006190552,0.00007676009],"domain_scores_gemma":[0.998736,0.000364212,0.0004160078,0.00009777182,0.00009720487,0.000288942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9597768,0.007976077,0.001187547,0.000728482,0.0008203755,0.00003906321,0.0000498412,0.0003032246,0.009024018,0.00003910003,0.000584647,0.01947083],"study_design_scores_gemma":[0.9216709,0.07381444,0.002811229,0.0000279536,0.0003504921,0.00003955182,0.00001122614,0.0002012851,0.0007899019,0.00002713953,0.0002481873,0.000007647629],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935365,0.003244045,0.000434881,0.0003403798,0.0001687865,0.001199817,0.0003986376,0.00005324441,0.0006235868],"genre_scores_gemma":[0.9918815,0.00264143,0.001284812,0.0005765797,0.0003297149,0.001361279,0.0006782909,0.00001638713,0.001230076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003782111,"threshold_uncertainty_score":0.0141716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01421514111082398,"score_gpt":0.2685552876145689,"score_spread":0.2543401465037449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}