{"id":"W2896559962","doi":"10.1016/s0140-6736(18)32463-2","title":"Efficacy and safety of filgotinib, a selective Janus kinase 1 inhibitor, in patients with active ankylosing spondylitis (TORTUGA): results from a randomised, placebo-controlled, phase 2 trial","year":2018,"lang":"en","type":"article","venue":"The Lancet","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":256,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Galápagos; Gilead Sciences","keywords":"Medicine; Ankylosing spondylitis; Placebo; Janus kinase inhibitor; Internal medicine; Clinical endpoint; Clinical trial; Spondylitis; Surgery; Physical therapy; Tofacitinib; Rheumatoid arthritis; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003407558,0.0002320343,0.001182297,0.00007570478,0.0001422694,0.00001511601,0.00007501687,0.00007074266,0.00004474764],"category_scores_gemma":[0.0007649673,0.0001380329,0.00007453382,0.0002164803,0.0002727369,0.00007174638,0.00004977433,0.0001931631,0.000003980098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009017315,"about_ca_system_score_gemma":0.00007779532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004629134,"about_ca_topic_score_gemma":0.0002436399,"domain_scores_codex":[0.9983456,0.0002103546,0.0004717906,0.0003655152,0.0002788392,0.0003278923],"domain_scores_gemma":[0.9982387,0.0008893973,0.000274651,0.0003539665,0.0001607622,0.00008250945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9829028,0.001138674,0.003652643,0.000008226592,0.0005494901,0.0000427702,0.002954426,4.941456e-7,0.00005906812,0.000006486714,0.0003750272,0.008309911],"study_design_scores_gemma":[0.9179794,0.006670274,0.07269988,0.0004177634,0.0003162569,0.000003661933,0.0001823651,0.00001621835,0.0008729324,0.00003379402,0.0006813091,0.0001262086],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910843,0.0002508656,0.000003178164,0.0003089851,0.0001798073,0.004181115,0.001993995,0.00002302729,0.001974663],"genre_scores_gemma":[0.9982219,0.00006786497,0.0001598902,0.0000971105,0.001003943,0.0001206382,0.0002644772,0.00002032737,0.00004380927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06904724,"threshold_uncertainty_score":0.5628819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0150066738315391,"score_gpt":0.2747319682570271,"score_spread":0.259725294425488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}