{"id":"W2896559962","doi":"10.1016/s0140-6736(18)32463-2","title":"Efficacy and safety of filgotinib, a selective Janus kinase 1 inhibitor, in patients with active ankylosing spondylitis (TORTUGA): results from a randomised, placebo-controlled, phase 2 trial","year":2018,"lang":"en","type":"article","venue":"The Lancet","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":256,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Galápagos; Gilead Sciences","keywords":"Medicine; Ankylosing spondylitis; Placebo; Janus kinase inhibitor; Internal medicine; Clinical endpoint; Clinical trial; Spondylitis; Surgery; Physical therapy; Tofacitinib; Rheumatoid arthritis; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001721656,0.001686019,0.002903978,0.0003429905,0.0004753749,0.001204077,0.0008292387,0.002342265,0.004189521],"category_scores_gemma":[0.002233591,0.0006282404,0.002775019,0.000370212,0.001295734,0.001257609,0.0003287751,0.003295516,0.000642162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007716053,"about_ca_system_score_gemma":0.0005449129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000918337,"about_ca_topic_score_gemma":0.001923875,"domain_scores_codex":[0.9993445,0.0003084824,0.00005462154,0.0001308074,0.00005948675,0.0001022076],"domain_scores_gemma":[0.9989488,0.0003676653,0.0002826959,0.0000703826,0.00006721979,0.0002633061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9741609,0.002150727,0.001162724,0.001373834,0.002763658,0.00006981294,0.00006965871,0.0001921868,0.003304553,0.00007778605,0.0008237118,0.01385059],"study_design_scores_gemma":[0.9483087,0.04307123,0.005468783,0.00007373492,0.001709586,0.00009384938,0.0000380208,0.0001681947,0.0002821875,0.0001435091,0.000620101,0.00002209751],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974975,0.02005566,0.0002632698,0.000979712,0.0004879937,0.0005661833,0.0009167128,0.00007186874,0.001683596],"genre_scores_gemma":[0.9908746,0.004666748,0.0003598149,0.001004043,0.0004320949,0.0004802336,0.001081327,0.00001290653,0.001088125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004189521,"threshold_uncertainty_score":0.01401532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0150066738315391,"score_gpt":0.2747319682570271,"score_spread":0.259725294425488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}