{"id":"W2896624720","doi":"10.1128/jvi.01098-18","title":"Naturally Occurring Single Mutations in Ebola Virus Observably Impact Infectivity","year":2018,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; Sanming Project of Medicine in Shenzhen; National Key Research and Development Program of China; Canadian Institutes of Health Research; National Institutes of Health; National Science and Technology Major Project; Youth Innovation Promotion Association of the Chinese Academy of Sciences","keywords":"Biology; Virology; Ebola virus; Nucleoprotein; Virulence; Virus; Tropism; Vero cell; Population; Viral replication; Mutation; Mutant; Ebolavirus; Polymerase; Tissue tropism; RNA; Serial passage; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002378713,0.0002284285,0.0002388847,0.0001748115,0.0001466964,0.0003207047,0.000180904,0.0003388379,0.0005882384],"category_scores_gemma":[0.0004941961,0.0001017992,0.0002183694,0.0001058428,0.0002855705,0.0002511293,0.0001945495,0.0004673187,0.0001093245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002879795,"about_ca_system_score_gemma":0.0001760035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006483044,"about_ca_topic_score_gemma":0.0007977586,"domain_scores_codex":[0.9997572,0.00007178291,0.00002552481,0.00004654572,0.00005418634,0.00004469468],"domain_scores_gemma":[0.999736,0.0001314978,0.00005578027,0.00002928856,0.00002201862,0.00002541075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000703019,0.00005177078,0.002068656,0.00002138475,0.000008356216,0.00008088428,0.00002690976,0.0001316717,0.9961927,0.00007903411,0.0000224208,0.001245902],"study_design_scores_gemma":[0.00001507596,0.001028687,0.02279358,0.00001556515,0.0000491475,0.001205279,0.0001098989,0.002623167,0.9705822,0.0001837718,0.001379896,0.00001371567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982286,0.0006672466,0.0006161131,0.00002899903,0.000009078504,0.000008859898,0.00007300716,0.00001156625,0.0003565437],"genre_scores_gemma":[0.9988457,0.0002223059,0.0006566244,0.00002154025,0.000004233383,0.000007512081,0.00006331313,0.000005881221,0.0001728593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006483044,"threshold_uncertainty_score":0.002089441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04268643844209185,"score_gpt":0.3922244190022336,"score_spread":0.3495379805601418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}