{"id":"W2896624720","doi":"10.1128/jvi.01098-18","title":"Naturally Occurring Single Mutations in Ebola Virus Observably Impact Infectivity","year":2018,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; Sanming Project of Medicine in Shenzhen; National Key Research and Development Program of China; Canadian Institutes of Health Research; National Institutes of Health; National Science and Technology Major Project; Youth Innovation Promotion Association of the Chinese Academy of Sciences","keywords":"Biology; Virology; Ebola virus; Nucleoprotein; Virulence; Virus; Tropism; Vero cell; Population; Viral replication; Mutation; Mutant; Ebolavirus; Polymerase; Tissue tropism; RNA; Serial passage; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005068982,0.00009421573,0.0003084393,0.0004517473,0.00007117589,0.00001981856,0.00007187302,0.000125281,0.0002605323],"category_scores_gemma":[0.0004656724,0.00006890606,0.0001528451,0.0003445319,0.000155129,0.0002235348,0.00003936142,0.0006267585,0.00004052309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002164075,"about_ca_system_score_gemma":0.0002030535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000330865,"about_ca_topic_score_gemma":0.0005529125,"domain_scores_codex":[0.998982,0.0001273679,0.0003512013,0.0001001154,0.0001730818,0.0002661961],"domain_scores_gemma":[0.9991356,0.0001358617,0.0001625378,0.0001088082,0.0003243854,0.0001328701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006262012,0.0006087608,0.1890619,0.00001350369,0.0001086397,0.000271673,0.0002687919,0.0001239821,0.7981958,0.00003797798,0.0004281553,0.01025457],"study_design_scores_gemma":[0.001966621,0.006178497,0.9646549,0.00005570329,0.00004776456,0.002133918,0.00003911799,0.0007947537,0.02128483,0.0004277545,0.002329971,0.00008617524],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972263,0.0001664365,0.0003834492,0.0004972034,0.0002719498,0.00009235147,0.0000030471,0.000009611072,0.001349666],"genre_scores_gemma":[0.9988096,0.00002394103,0.0002851069,0.0003860987,0.0004430968,0.000001507183,0.000001111201,0.0000103701,0.00003918921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.776911,"threshold_uncertainty_score":0.2852646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04268643844209185,"score_gpt":0.3922244190022336,"score_spread":0.3495379805601418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}