{"id":"W2896685834","doi":"10.1007/s40259-018-0309-y","title":"Emerging Technologies for Delivery of Biotherapeutics and Gene Therapy Across the Blood–Brain Barrier","year":2018,"lang":"en","type":"article","venue":"BioDrugs","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"Government of Canada","keywords":"Transcytosis; Biomanufacturing; Gene delivery; Blood–brain barrier; Transferrin receptor; Genetic enhancement; Nanocarriers; Medicine; Biology; Neuroscience; Computational biology; Immunology; Receptor; Central nervous system; Gene; Pharmacology; Drug; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001642282,0.000113025,0.00009984998,0.00002164205,0.0001323962,0.00001993325,0.0002237654,0.0001324084,0.000005321326],"category_scores_gemma":[0.00002996167,0.0000765369,0.00006589569,0.00005940653,0.0004108208,0.000003212782,0.00009568508,0.0000361936,0.00000159303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002012287,"about_ca_system_score_gemma":0.00002565878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001805281,"about_ca_topic_score_gemma":0.00001815857,"domain_scores_codex":[0.9993774,0.00001733366,0.0001395815,0.0002156403,0.00005564066,0.0001944093],"domain_scores_gemma":[0.9994746,0.00002247394,0.00006512977,0.0002992832,0.000121541,0.00001695935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009729505,0.00001863707,0.0008733839,0.000005882279,0.00009718465,1.646466e-7,0.0002860588,2.678154e-7,0.9469309,0.00003061585,0.0009580653,0.05070156],"study_design_scores_gemma":[0.0003975071,0.0005139336,0.0002952224,0.000006194078,0.00001010321,0.00000444274,0.0007084121,0.00002440451,0.9013749,0.000100503,0.09646425,0.0001000587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924968,0.005685263,0.0006554214,0.0007453362,0.0001030081,0.0001784822,0.00007997517,0.00001695095,0.00003869742],"genre_scores_gemma":[0.995881,0.002276954,0.0006348263,0.0006757617,0.0001468843,0.00002155786,0.00001390425,0.00001332344,0.0003358062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09550619,"threshold_uncertainty_score":0.3121084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01483342197156779,"score_gpt":0.2858330559010852,"score_spread":0.2709996339295174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}