{"id":"W2896725950","doi":"10.1093/annonc/mdy288.094","title":"Potential drug cost impact of dual agent immunotherapy (DAIO) with nivolumab (N) plus ipilimumab (I) in patients with DNA mismatch repair deficient (dMMR) metastatic colorectal cancer (mCRC) in Canada","year":2018,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care South East; Queen's University","funders":"","keywords":"Medicine; Nivolumab; Ipilimumab; Colorectal cancer; Oncology; Internal medicine; Context (archaeology); Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001031033,0.0004025743,0.0004642579,0.001263684,0.0007015486,0.001757953,0.000778043,0.0003980383,0.002291174],"category_scores_gemma":[0.004029815,0.0002840401,0.001401781,0.002225248,0.000432984,0.0004306334,0.0007855671,0.0007569564,0.0001098038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.07234982,"about_ca_system_score_gemma":0.04422364,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9526387,"about_ca_topic_score_gemma":0.9686084,"domain_scores_codex":[0.9989278,0.0002826994,0.00005346649,0.00007167365,0.000292876,0.0003715989],"domain_scores_gemma":[0.998188,0.0004352022,0.0003404463,0.00002289672,0.000606857,0.000406658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.007205322,0.0004217365,0.5866062,0.002212379,0.002534044,0.001944517,0.0005250844,0.227602,0.001428891,0.01006512,0.01786176,0.1415929],"study_design_scores_gemma":[0.001152144,0.002204155,0.7400533,0.001500704,0.004024994,0.001786366,0.003733307,0.2005006,0.002469989,0.003329618,0.03901079,0.0002339792],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9539525,0.01059215,0.001363596,0.005046952,0.00007817151,0.0004166502,0.01392903,0.00004822763,0.01457281],"genre_scores_gemma":[0.9936819,0.002246768,0.0009111421,0.000231579,0.0000134228,0.00004162997,0.001716414,0.000009536364,0.001147621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07234982,"threshold_uncertainty_score":0.5249372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1539060253546396,"score_gpt":0.4119067251298072,"score_spread":0.2580006997751676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}