{"id":"W2896784052","doi":"10.1101/442533","title":"Telomeric dysfunction triggers an unstable growth arrest leading to irreparable genomic lesions and entry into cellular senescence","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Institute of Cancer Research; Institut Du Cancer de Montréal","keywords":"Telomere; Shelterin; Genome instability; Senescence; DNA damage; Biology; Mitosis; Cell biology; Cell cycle checkpoint; Mitotic catastrophe; Cell cycle; Genetics; DNA; Cell; Gene; DNA-binding protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001175053,0.0002755246,0.0002018471,0.0002299888,0.0001045098,0.0002465869,0.0001305902,0.0003401726,0.001801643],"category_scores_gemma":[0.0001046857,0.0000937907,0.0001749002,0.0001224529,0.0001949274,0.00009651007,0.000295415,0.0004463753,0.0005056789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002023687,"about_ca_system_score_gemma":0.0001316623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001876802,"about_ca_topic_score_gemma":0.0001834483,"domain_scores_codex":[0.9998858,0.00002105454,0.00001074518,0.00002574215,0.00002279663,0.00003389129],"domain_scores_gemma":[0.9999148,0.00001351952,0.00002457965,0.00001616466,0.000005792348,0.00002518237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002065474,0.00003677313,0.0003540975,0.00003125702,0.000006552609,0.0002798418,0.00001689564,0.00007542074,0.9972361,0.0002012435,0.00009960098,0.001455738],"study_design_scores_gemma":[0.00002263697,0.0004675374,0.006235218,0.00001085909,0.00001239173,0.001168776,0.00003498821,0.001010613,0.987201,0.0002531882,0.003578607,0.000004273992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916824,0.002003757,0.002966856,0.0001598335,0.00007946065,0.0000237122,0.0003492473,0.0001612292,0.002573448],"genre_scores_gemma":[0.9960369,0.0003664283,0.0006194038,0.00005395043,0.0000122052,0.00001198979,0.0002179777,0.00001073666,0.002670353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001801643,"threshold_uncertainty_score":0.006027102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01511088587562149,"score_gpt":0.234578120418668,"score_spread":0.2194672345430466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}