{"id":"W2896787860","doi":"10.1093/ndt/gfy310","title":"From mice to men: is that fancy new biomarker clinically relevant?","year":2018,"lang":"en","type":"letter","venue":"Nephrology Dialysis Transplantation","topic":"Electrolyte and hormonal disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Medicine; Biomarker; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002792245,0.0005623522,0.001147716,0.0005083234,0.0001034482,0.00003958237,0.0003903555,0.002414857,0.002653918],"category_scores_gemma":[0.00005916907,0.0005240402,0.0005928103,0.0004042931,0.0001295898,0.0001078546,0.00002107197,0.001343602,0.001663825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006114442,"about_ca_system_score_gemma":0.0004551164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001695253,"about_ca_topic_score_gemma":0.0005641077,"domain_scores_codex":[0.9962097,0.0002436222,0.0008828993,0.001131607,0.000856321,0.0006758589],"domain_scores_gemma":[0.9979961,0.0006135424,0.0003030281,0.0006372262,0.0001647631,0.0002853421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002822521,0.00005526973,0.0006457616,0.0001023887,0.001703461,0.0005802601,0.001232558,2.980025e-7,0.01008782,0.000001583744,0.9692071,0.01356096],"study_design_scores_gemma":[0.004972043,0.00125368,0.03514389,0.0002589613,0.008213955,0.0001146258,0.00002623725,0.0001065911,0.001858522,0.001397682,0.9458389,0.0008148614],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.04684098,0.0005914547,0.005242503,0.9380243,0.0002904078,0.0008472034,0.0003254763,0.0001890421,0.007648665],"genre_scores_gemma":[0.008207902,0.004827655,0.001574683,0.966515,0.005941204,0.00004225628,0.008568328,0.0001188831,0.004204086],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03863308,"threshold_uncertainty_score":0.9997211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02427044322953476,"score_gpt":0.2964411380333739,"score_spread":0.2721706948038391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}