{"id":"W2896825577","doi":"10.1007/s10637-018-0680-z","title":"Canadian Cancer Trials Group (CCTG) IND215: A phase Ib study of Selumetinib in patients with untreated advanced or metastatic NSCLC who are receiving standard chemotherapy regimens","year":2018,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hamilton Health Sciences; University of Toronto; Queen's University; BC Cancer Agency; Princess Margaret Cancer Centre; Ottawa Hospital; Juravinski Cancer Centre","funders":"Canadian Cancer Society Research Institute","keywords":"Selumetinib; Medicine; Carboplatin; Pemetrexed; Cohort; Internal medicine; Adverse effect; Chemotherapy; Tolerability; Neutropenia; Oncology; Cisplatin; Cancer; Gastroenterology; KRAS","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003388472,0.0002505057,0.0007614408,0.0003537439,0.0001188593,0.00002483813,0.00008811368,0.00005150172,0.0004728754],"category_scores_gemma":[0.0003462063,0.0001760314,0.00004745549,0.0008345756,0.0001278476,0.000186869,0.000009955462,0.0001196757,0.000003873033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008296452,"about_ca_system_score_gemma":0.003086192,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.05619707,"about_ca_topic_score_gemma":0.2142821,"domain_scores_codex":[0.9979449,0.0001765317,0.0006392166,0.0003859962,0.0005569088,0.0002964307],"domain_scores_gemma":[0.9981416,0.0002008292,0.0004784208,0.0002508832,0.0004940277,0.0004342525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01640767,0.003287321,0.8655604,0.0001489281,0.003198312,0.00006980712,0.04379717,0.0002522885,0.000331976,0.0001571327,0.007277578,0.05951142],"study_design_scores_gemma":[0.2033064,0.01324918,0.7624226,0.003426939,0.001760787,0.000006080795,0.006387832,0.0001771057,0.002487692,0.0006763953,0.00539662,0.0007023431],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944368,0.00009012626,0.00002668777,0.00214694,0.00009821291,0.002525952,0.0004403805,0.00002823207,0.0002066414],"genre_scores_gemma":[0.9935696,0.00001740837,0.003926186,0.0009270078,0.0001125837,0.0002136642,0.0002485558,0.00004613246,0.0009388954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1868987,"threshold_uncertainty_score":0.9500878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03154237553643747,"score_gpt":0.3657243787929642,"score_spread":0.3341820032565267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}