{"id":"W2896829387","doi":"10.1093/femsle/fny250","title":"Streptomyces protein secretion and its application in biotechnology","year":2018,"lang":"en","type":"review","venue":"FEMS Microbiology Letters","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Environment and Climate Change Canada","keywords":"Secretion; Bacteria; Heterologous; Downstream processing; Biology; Secretory protein; Proteases; Streptomyces; Recombinant DNA; Biochemistry; Inclusion bodies; Protein biosynthesis; Microbiology; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004375884,0.0008319209,0.0009254087,0.002396319,0.0003235003,0.001191588,0.0005245109,0.000817234,0.002282923],"category_scores_gemma":[0.0003861409,0.0003420459,0.0005219944,0.002695456,0.0005774486,0.001199999,0.0007041687,0.001557483,0.002179262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007946819,"about_ca_system_score_gemma":0.0009632977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007492732,"about_ca_topic_score_gemma":0.0009235312,"domain_scores_codex":[0.9997405,0.00003135711,0.00003213128,0.00004513391,0.0001211299,0.00002969822],"domain_scores_gemma":[0.9998555,0.00005121344,0.00002314905,0.000009344235,0.00003630423,0.00002438116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006529496,0.00007291199,0.0002326864,0.01478293,0.00005445327,0.000343943,0.000103115,0.0007709951,0.01673605,0.01249091,0.01195896,0.9423878],"study_design_scores_gemma":[0.000007135553,0.00009068655,0.0005307423,0.001094353,0.00003348606,0.0008109744,0.00004092037,0.0001259729,0.003977354,0.002299431,0.9909728,0.00001624059],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000701964,0.9944444,0.0007604223,0.0002535574,0.0002669922,0.000009204699,0.00003019942,0.00002669001,0.003506513],"genre_scores_gemma":[0.003260001,0.994453,0.0007489822,0.0001221538,0.00009548477,0.000008854674,0.00005757559,0.000004634469,0.001249214],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002396319,"threshold_uncertainty_score":0.007637143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01389260204326655,"score_gpt":0.2829079970276894,"score_spread":0.2690153949844228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}