{"id":"W2896839095","doi":"10.1002/jcp.27519","title":"Predictive and therapeutic biomarkers in chimeric antigen receptor T‐cell therapy: A clinical perspective","year":2018,"lang":"en","type":"review","venue":"Journal of Cellular Physiology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute for Medical Research Development; Tehran University of Medical Sciences and Health Services","keywords":"Chimeric antigen receptor; Medicine; Immunotherapy; Biomarker; Clinical trial; Cell therapy; Adverse effect; Cancer; Immunology; Oncology; Cell; Pharmacology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00189607,0.0005367001,0.003655464,0.0007953754,0.00005527426,0.00002020158,0.0004019777,0.0007419271,0.001093001],"category_scores_gemma":[0.0001535054,0.0003617448,0.001271508,0.0006166536,0.0008581736,0.00005961565,0.0001135886,0.001891017,0.0000515758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003585022,"about_ca_system_score_gemma":0.001421405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002155584,"about_ca_topic_score_gemma":0.000001122536,"domain_scores_codex":[0.9948247,0.001995259,0.001597044,0.0006270898,0.0004325197,0.0005233562],"domain_scores_gemma":[0.996601,0.0007745794,0.00133555,0.0004981458,0.0004890121,0.0003016978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00648704,0.002020004,0.0003060008,0.003344058,0.009248243,0.0003241298,0.001159593,2.647231e-7,0.05385137,0.00002013133,0.001407867,0.9218313],"study_design_scores_gemma":[0.004215085,0.008911259,0.0009338623,0.003730075,0.0007746494,0.0004546484,0.0004166545,0.00002082919,0.000361459,0.0003107544,0.9794506,0.0004201434],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0145938,0.9826069,0.00002002491,0.00009195676,0.0006371875,0.001207948,0.0000118556,0.00001156267,0.0008187131],"genre_scores_gemma":[0.001641542,0.995653,0.0001597676,0.000110821,0.001897782,0.00001892719,0.00001757248,0.0001096665,0.0003909359],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9780427,"threshold_uncertainty_score":0.9998835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08719668679768336,"score_gpt":0.4173001961641955,"score_spread":0.3301035093665121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}