{"id":"W2896928282","doi":"10.3389/fphar.2018.01168","title":"GLP-1 Improves Adipocyte Insulin Sensitivity Following Induction of Endoplasmic Reticulum Stress","year":2018,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"National Natural Science Foundation of China","keywords":"Endocrinology; Unfolded protein response; Internal medicine; Thapsigargin; Endoplasmic reticulum; PI3K/AKT/mTOR pathway; Adipose tissue; Insulin resistance; Insulin; Protein kinase B; Insulin receptor; CHOP; White adipose tissue; Adipocyte; Chemistry; Biology; Signal transduction; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002232692,0.0001973036,0.0002942642,0.0001362519,0.00006448424,0.000008388037,0.0001483507,0.0002118156,0.0000287503],"category_scores_gemma":[0.00009589704,0.0002046805,0.0001361904,0.000165378,0.000326047,0.00001153247,0.0001264751,0.000157821,0.000004446229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003062664,"about_ca_system_score_gemma":0.000108208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006273641,"about_ca_topic_score_gemma":0.00004636929,"domain_scores_codex":[0.9985071,0.0002282606,0.0003241719,0.0004451372,0.0001259829,0.0003693276],"domain_scores_gemma":[0.9993964,0.00001834923,0.0001530191,0.0002308816,0.00008485855,0.0001165366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005473113,0.0001956602,0.03913734,0.00004321845,0.0001758408,0.00004978142,0.000101522,0.00007347976,0.9447446,0.0000125692,0.01065977,0.004258846],"study_design_scores_gemma":[0.002074922,0.0003311364,0.006759746,0.00002208568,0.00009427718,0.00001396995,0.0002104735,0.001259378,0.9853664,0.0000692246,0.003579251,0.0002191493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921988,0.001204734,0.001550388,0.00007816594,0.003787266,0.0002661858,0.00005352513,0.00001513483,0.0008457731],"genre_scores_gemma":[0.9969836,0.0003475781,0.001715252,0.0001936277,0.0005132132,0.00003265072,0.00007066865,0.00002361269,0.0001198137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04062174,"threshold_uncertainty_score":0.8346627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005209533031291341,"score_gpt":0.2551902426259176,"score_spread":0.2499807095946262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}