{"id":"W2896952615","doi":"10.1158/1078-0432.ccr-18-1854","title":"Ketoconazole and Posaconazole Selectively Target HK2-expressing Glioblastoma Cells","year":2018,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; Occupational Cancer Research Centre; Princess Margaret Cancer Centre","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Posaconazole; Ketoconazole; Glioma; Azole; Cancer research; Biology; Pharmacology; In vivo; In vitro; Biochemistry; Itraconazole; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001591552,0.0001769884,0.0002897955,0.00008390522,0.0003170041,0.00008402335,0.0003276943,0.0002924939,0.0003640993],"category_scores_gemma":[0.0003352828,0.0001655914,0.0001141453,0.0002412393,0.001085092,0.00001107985,0.0004060737,0.0005024538,0.00005383594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003052835,"about_ca_system_score_gemma":0.0005617199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001498329,"about_ca_topic_score_gemma":0.0003598178,"domain_scores_codex":[0.9974286,0.0003839805,0.0003795161,0.0007606143,0.0003722692,0.0006750398],"domain_scores_gemma":[0.9984308,0.0001268804,0.00008044836,0.0004131016,0.0006041173,0.0003446282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001361428,0.0001523204,0.004590181,0.00003667078,0.0001022901,0.000001917893,0.0001003265,0.000004763432,0.8526894,0.00009754695,0.1120214,0.02884169],"study_design_scores_gemma":[0.001097644,0.0007706042,0.006652419,0.00002707,0.00001166261,0.000004829563,0.00004016431,0.00007259614,0.3655464,0.000260339,0.6253232,0.0001930791],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875182,0.007061871,0.0003110002,0.0004698744,0.00142981,0.0004576043,0.0000689658,0.00002223021,0.002660433],"genre_scores_gemma":[0.9822712,0.002196477,0.0004142603,0.0003934577,0.01003828,0.0001377425,0.0000111819,0.00004819276,0.004489226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5133018,"threshold_uncertainty_score":0.6752623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07158397649095095,"score_gpt":0.4482799889607672,"score_spread":0.3766960124698163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}