{"id":"W2896953490","doi":"10.1016/j.ccell.2018.09.001","title":"MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis","year":2018,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Janssen Pharmaceuticals; Takeda Canada; Terry Fox Research Institute; Ontario Ministry of Research, Innovation and Science; Novartis Pharma; Ontario Genomics Institute; University of Pennsylvania; Canada Foundation for Innovation; Wellcome Trust; Ontario Institute for Cancer Research; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; AbbVie; Janssen Biotech; Canadian Institutes of Health Research; Innovative Medicines Initiative; Wellcome; Merck; Pfizer; Boehringer Ingelheim","keywords":"Psychological repression; Histone methyltransferase; Carcinogenesis; Histone; Methyltransferase; Cell biology; Biology; Epigenetics; Cancer research; Genetics; Methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009586415,0.0001031646,0.00007838625,0.0000150434,0.0001087718,0.00001744577,0.00008760062,0.00004947382,0.00007262276],"category_scores_gemma":[0.0000064247,0.00006895039,0.00002780236,0.00005332312,0.0000859597,0.000003841516,0.00002089375,0.00004151482,0.000003416249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002011365,"about_ca_system_score_gemma":0.00004785173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001606637,"about_ca_topic_score_gemma":0.0007732455,"domain_scores_codex":[0.9993587,0.00004059239,0.0000936469,0.0002829498,0.00009572622,0.0001284109],"domain_scores_gemma":[0.9995678,0.00001039478,0.00002972605,0.0002033692,0.000105421,0.00008326695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001538261,0.00001473531,0.0003372257,0.000008361455,0.00001437073,7.198564e-7,0.0004747822,0.00009266377,0.9931861,0.00001047009,0.0005789492,0.005127815],"study_design_scores_gemma":[0.0002730287,0.0003284881,0.005248562,0.00001378391,0.00002707569,9.346991e-7,0.000105796,0.0000225281,0.9260812,0.0000178744,0.06776788,0.0001128461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777415,0.005317783,0.01471321,0.0005623752,0.000156433,0.0001615504,0.00002172759,0.000005031899,0.001320351],"genre_scores_gemma":[0.9965105,0.0007416512,0.0006080429,0.0004456872,0.0003307955,0.00004435,0.00002076485,0.00001609641,0.001282114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06718893,"threshold_uncertainty_score":0.2811716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008425975419162287,"score_gpt":0.2810663316266492,"score_spread":0.2726403562074869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}