{"id":"W2896953490","doi":"10.1016/j.ccell.2018.09.001","title":"MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis","year":2018,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Janssen Pharmaceuticals; Takeda Canada; Terry Fox Research Institute; Ontario Ministry of Research, Innovation and Science; Novartis Pharma; Ontario Genomics Institute; University of Pennsylvania; Canada Foundation for Innovation; Wellcome Trust; Ontario Institute for Cancer Research; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; AbbVie; Janssen Biotech; Canadian Institutes of Health Research; Innovative Medicines Initiative; Wellcome; Merck; Pfizer; Boehringer Ingelheim","keywords":"Psychological repression; Histone methyltransferase; Carcinogenesis; Histone; Methyltransferase; Cell biology; Biology; Epigenetics; Cancer research; Genetics; Methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001787608,0.0002133519,0.0001528023,0.0002502371,0.0002508491,0.000545972,0.0003464782,0.0003388452,0.00167299],"category_scores_gemma":[0.0002662755,0.0002584676,0.0002433291,0.0001655699,0.0003090509,0.0003073373,0.0005350314,0.0006205474,0.0008180762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005599321,"about_ca_system_score_gemma":0.000171219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007057425,"about_ca_topic_score_gemma":0.00123194,"domain_scores_codex":[0.999853,0.00002251222,0.000007921229,0.00003280247,0.00004128171,0.00004250708],"domain_scores_gemma":[0.9998574,0.00002484639,0.00002920866,0.00002960927,0.00001412896,0.000044707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000158322,0.00001941263,0.0008328032,0.00001582739,0.000008821528,0.00006580839,0.000009430342,0.000132858,0.9947666,0.00137683,0.0001434394,0.00246995],"study_design_scores_gemma":[0.0000232766,0.00008417208,0.0064829,0.000004961444,0.00001215867,0.000290486,0.0000276543,0.002957709,0.9835076,0.0007658756,0.00583774,0.00000536673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787782,0.002394974,0.01054114,0.0006562384,0.0001016482,0.0000159128,0.0003314272,0.0002956454,0.006884804],"genre_scores_gemma":[0.9959471,0.0003512523,0.001040815,0.00006077126,0.00001146843,0.000005525837,0.0001903317,0.00003942359,0.00235323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00167299,"threshold_uncertainty_score":0.005596697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008425975419162287,"score_gpt":0.2810663316266492,"score_spread":0.2726403562074869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}