{"id":"W2896964091","doi":"10.1021/acs.jpcb.8b07919","title":"Methionine 170 is an Environmentally Sensitive Membrane Anchor in the Disordered HVR of K-Ras4B","year":2018,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry B","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Oak Ridge National Laboratory; Lawrence Livermore National Laboratory; Canadian Institutes of Health Research; Frederick National Laboratory for Cancer Research; Laboratory Directed Research and Development; U.S. Department of Energy; Los Alamos National Laboratory; National Nuclear Security Administration; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Membrane; Chemistry; Microsecond; Biophysics; Intermolecular force; Cationic polymerization; Molecular dynamics; Effector; Biochemistry; Molecule; Biology; Polymer chemistry; Computational chemistry; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004247183,0.0001013181,0.0001488036,0.000009334441,0.0000502741,0.000007672214,0.0002425296,0.00005500349,0.00003582697],"category_scores_gemma":[0.00004513923,0.00005910114,0.00009904402,0.00007255236,0.0002349438,0.000007284188,0.00004442965,0.0001521096,0.0000015174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009497448,"about_ca_system_score_gemma":0.00003291958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005623383,"about_ca_topic_score_gemma":0.000001813785,"domain_scores_codex":[0.999236,0.0001239365,0.0002167872,0.00009539054,0.0002158998,0.0001120209],"domain_scores_gemma":[0.9993973,0.00003406667,0.0002196137,0.0002337849,0.00007331147,0.00004195084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002012921,0.0001602984,0.00001972442,0.00001213116,0.00003289643,0.000002128166,0.0008759251,0.00009669226,0.9979956,0.00001043635,0.00006421287,0.0005286394],"study_design_scores_gemma":[0.0004555479,0.0002734095,0.0005881194,0.00002357,0.00003591351,0.00003689837,0.0006336438,0.00030172,0.9968123,0.0001732939,0.0005939055,0.00007171465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998491,0.0001159257,0.0004233158,0.0004666685,0.000009672115,0.00006674956,0.000009605875,0.000001058003,0.0004160164],"genre_scores_gemma":[0.9990302,0.00003017025,0.0001053689,0.0002153065,0.0005498998,0.000001106629,0.000009681431,0.00000828767,0.00005002144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00118336,"threshold_uncertainty_score":0.2410075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019606722090401,"score_gpt":0.2582605481756658,"score_spread":0.2480644809547618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}