{"id":"W2897008012","doi":"10.1093/annonc/mdy283.098","title":"Clinical outcomes of patients with metastatic renal cell carcinoma (mRCC) treated with vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) and mammalian target of rapamycin inhibitors (mTORI) after immuno-oncology (IO) checkpoint inhibitors","year":2018,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Princess Margaret Cancer Centre; University of Calgary","funders":"","keywords":"Medicine; Axitinib; Pazopanib; Sunitinib; Temsirolimus; Sorafenib; Everolimus; Cabozantinib; Discontinuation; Internal medicine; Hazard ratio; Oncology; Renal cell carcinoma; Tyrosine-kinase inhibitor; Lenvatinib; Urology; Cancer; Hepatocellular carcinoma; PI3K/AKT/mTOR pathway; Confidence interval; Discovery and development of mTOR inhibitors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006752869,0.0001327697,0.0004342046,0.0004447989,0.0003030445,0.0005811285,0.0002524328,0.0003099881,0.0009821446],"category_scores_gemma":[0.002093518,0.00009336175,0.0005750714,0.0006962692,0.0002180574,0.0003559186,0.0003605909,0.0004698592,0.0001706082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008275723,"about_ca_system_score_gemma":0.000443535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003086763,"about_ca_topic_score_gemma":0.004123888,"domain_scores_codex":[0.9995431,0.00008221843,0.00006652995,0.0001176045,0.00009142218,0.00009920936],"domain_scores_gemma":[0.9975511,0.0003217187,0.001489347,0.00005986284,0.0001677976,0.000410163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007919615,0.00007384466,0.9964749,0.00001807744,0.00007540366,0.00008908989,0.00004214538,0.0001377771,0.00015993,0.00001119821,0.0001550867,0.001970452],"study_design_scores_gemma":[0.000041561,0.0005559017,0.9983223,0.000007333324,0.00006335091,0.0003414996,0.00007919634,0.0001914236,0.00009303273,0.00001564326,0.0002844585,0.000004402187],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986003,0.0004086704,0.00002562036,0.00003940516,0.000003917037,0.000009300546,0.0005421945,0.000001934333,0.0003686384],"genre_scores_gemma":[0.9988781,0.00008889407,0.00002095573,0.0000221089,0.000008092883,0.000008222443,0.0008813205,9.795409e-7,0.00009142201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003086763,"threshold_uncertainty_score":0.006137609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03005668430230609,"score_gpt":0.3013022353966353,"score_spread":0.2712455510943292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}