{"id":"W2897042078","doi":"10.1101/436113","title":"Variably methylated regions in the newborn epigenome: environmental, genetic and combined influences","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia; McGill University; Douglas Mental Health University Institute","funders":"National Institute of Environmental Health Sciences; Fogarty International Center; National Institutes of Health; Sigrid Juséliuksen Säätiö; Signe ja Ane Gyllenbergin Säätiö; Helse- og Omsorgsdepartementet; Päivikki ja Sakari Sohlbergin Säätiö; National Institute of Neurological Disorders and Stroke; Novo Nordisk; National Institute of Child Health and Human Development; Juho Vainion Säätiö; Jane ja Aatos Erkon Säätiö; Lastentautien Tutkimussäätiö; Norges Forskningsråd; Academy of Finland; Tommy's; Bill and Melinda Gates Foundation; Eunice Kennedy Shriver National Institute of Child Health and Human Development; European Commission; Suomen Lääketieteen Säätiö; British Heart Foundation; Helsingin Yliopisto","keywords":"dNaM; Epigenetics; Genome-wide association study; DNA methylation; Biology; Genetics; Genetic association; Epigenome; Gene–environment interaction; Computational biology; Single-nucleotide polymorphism; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001379344,0.0004309605,0.0004988846,0.0005199929,0.0002885027,0.0007426636,0.0004327683,0.0003228613,0.002334387],"category_scores_gemma":[0.004476356,0.0001938742,0.0006864553,0.0008944788,0.0004882607,0.000277299,0.000821452,0.0005421449,0.0001398015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003160893,"about_ca_system_score_gemma":0.0004726753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006642277,"about_ca_topic_score_gemma":0.006846845,"domain_scores_codex":[0.9988737,0.0004509684,0.00006802189,0.0003938187,0.0001153314,0.0000981813],"domain_scores_gemma":[0.9980137,0.001079625,0.0004275279,0.0002400207,0.0001073213,0.0001316466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005798377,0.00003331111,0.9600945,0.0001213565,0.001930648,0.0003080687,0.000355968,0.002623743,0.01287626,0.001070035,0.0003237424,0.01968247],"study_design_scores_gemma":[0.00001124652,0.00009291093,0.9859402,0.00004736966,0.0005670772,0.0005190913,0.0002018947,0.006247244,0.002171013,0.003090876,0.001091902,0.00001918765],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865547,0.002361836,0.008450089,0.0003236998,0.00003118557,0.00001523852,0.001352176,0.00006118895,0.0008498571],"genre_scores_gemma":[0.9974885,0.0002877385,0.001704102,0.00005325897,0.0000117721,0.00001102719,0.0002343701,0.00001678774,0.0001924408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006642277,"threshold_uncertainty_score":0.01320726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01141544597379845,"score_gpt":0.2212372878854104,"score_spread":0.2098218419116119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}