{"id":"W2897043380","doi":"10.1111/bjd.17318","title":"Efficacy and safety of brodalumab in patients with psoriasis who had inadequate responses to ustekinumab: subgroup analysis of two randomized phase <scp>III</scp> trials","year":2018,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Ortho Dermatologics","keywords":"Ustekinumab; Medicine; Psoriasis Area and Severity Index; Adverse effect; Psoriasis; Internal medicine; Randomized controlled trial; Psoriatic arthritis; Subgroup analysis; Body surface area; Dermatology; Adalimumab; Meta-analysis; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01082599,0.001660107,0.006126046,0.001136611,0.0004039062,0.001779121,0.0008537719,0.001604891,0.002199426],"category_scores_gemma":[0.01195958,0.000554543,0.01553442,0.00113868,0.0005082742,0.0007660982,0.000684082,0.001364331,0.000259469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008621768,"about_ca_system_score_gemma":0.001070003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008575954,"about_ca_topic_score_gemma":0.002385104,"domain_scores_codex":[0.9908746,0.004710562,0.00227164,0.0009281939,0.00077004,0.000444994],"domain_scores_gemma":[0.9936039,0.003309054,0.001580924,0.0007953807,0.0004159692,0.0002947841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.7796111,0.0005781048,0.02585947,0.008287317,0.1497315,0.0002889471,0.000178532,0.0007189284,0.003682158,0.0001810274,0.001540806,0.02934195],"study_design_scores_gemma":[0.5469075,0.02966576,0.1133795,0.001549033,0.2954687,0.0006492671,0.0003255731,0.002064868,0.002363445,0.001490075,0.005964101,0.0001721195],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8610395,0.1203616,0.002901386,0.001227782,0.001137336,0.00602051,0.004113212,0.0001568665,0.003041861],"genre_scores_gemma":[0.9849803,0.007040628,0.001063136,0.0009523853,0.0003606686,0.0030068,0.001907936,0.00003653199,0.0006515766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01082599,"threshold_uncertainty_score":0.05725402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01652644033453659,"score_gpt":0.2833830834402225,"score_spread":0.2668566431056859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}