{"id":"W2897046087","doi":"10.7554/elife.41973","title":"Dynamic neuromuscular remodeling precedes motor-unit loss in a mouse model of ALS","year":2018,"lang":"en","type":"article","venue":"eLife","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal","funders":"Canadian Institutes of Health Research; ALS Society of Canada; Robert Packard Center for ALS Research, Johns Hopkins University; Fonds de Recherche du Québec - Santé; Muscular Dystrophy Association","keywords":"Denervation; Neuromuscular junction; Neuroscience; Synapse; Biology; Motor neuron; Motor unit; Neuron; Degeneration (medical); Anatomy; Medicine; Pathology; Spinal cord","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003226493,0.0007961114,0.0006126539,0.00140133,0.0003760305,0.0005837909,0.0005338328,0.001097049,0.002681841],"category_scores_gemma":[0.0002400301,0.0005540047,0.0004683741,0.0003563672,0.0006247867,0.0005867819,0.0004838576,0.001775279,0.000820934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007536886,"about_ca_system_score_gemma":0.0003280453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001202017,"about_ca_topic_score_gemma":0.003471528,"domain_scores_codex":[0.999617,0.00003980435,0.00003794573,0.0001262363,0.0001077738,0.00007132679],"domain_scores_gemma":[0.9995431,0.00003570171,0.0002030748,0.00003288124,0.00002529772,0.0001601261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003182257,0.000152608,0.0008617343,0.00004989807,0.00001844656,0.0005677535,0.00007716176,0.0001902903,0.9953056,0.0002687599,0.0001663117,0.002023219],"study_design_scores_gemma":[0.0002472071,0.002738517,0.07461053,0.0001582586,0.0001471602,0.004973263,0.0004072118,0.006304352,0.903016,0.001135484,0.006212404,0.00004961008],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908953,0.001436733,0.003688894,0.0004260263,0.00007320749,0.00006679949,0.001044254,0.0005355729,0.001833256],"genre_scores_gemma":[0.9803535,0.001346911,0.004080536,0.0001953753,0.00002259923,0.0001583837,0.0007765547,0.0001666518,0.01289949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002681841,"threshold_uncertainty_score":0.008971691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05551110634018679,"score_gpt":0.3362662662023375,"score_spread":0.2807551598621507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}