{"id":"W2897073164","doi":"10.1021/acs.est.8b04487","title":"Down-Regulation of <i>hspb9</i> and <i>hspb11</i> Contributes to Wavy Notochord in Zebrafish Embryos Following Exposure to Polychlorinated Diphenylsulfides","year":2018,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Carleton University; Environment and Climate Change Canada","funders":"Anhui Provincial Department of Education; Natural Science Foundation of Anhui Province; China Scholarship Council; National Natural Science Foundation of China; Canada Research Chairs","keywords":"Notochord; Zebrafish; Gene knockdown; Biology; Cell biology; Embryo; Endocrinology; Internal medicine; Anatomy; Embryogenesis; Gene; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002577857,0.0001538809,0.0001720803,0.0004317886,0.0001268692,0.00002035303,0.0003106941,0.0001743808,0.00001450608],"category_scores_gemma":[0.00008297732,0.0001586957,0.00003614306,0.0008181246,0.0008089247,0.00002854091,0.0002284149,0.00006829672,0.00001363918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008638552,"about_ca_system_score_gemma":0.00002427635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002630174,"about_ca_topic_score_gemma":0.00008615322,"domain_scores_codex":[0.9986033,0.00001940082,0.0002776533,0.0005446406,0.0002156189,0.0003393971],"domain_scores_gemma":[0.9994772,0.000006708937,0.00006329085,0.0003419165,0.00001872446,0.00009212529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006188601,0.00004052126,0.05005998,0.000001999331,0.000006664964,5.617042e-7,0.00009071528,0.00005002406,0.9468303,0.0001462512,0.0000313415,0.002679698],"study_design_scores_gemma":[0.0004615514,0.0005792721,0.2126424,0.00001693054,0.000005525958,0.00000346873,0.0001819108,0.00002100167,0.7830514,0.0001760623,0.002726847,0.0001336528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967186,0.0001235485,0.00162912,0.0006960591,0.000153963,0.0005421957,0.00001589423,0.00002690444,0.00009365188],"genre_scores_gemma":[0.9987141,0.000005919963,0.0008786538,0.000233341,0.0000234742,0.00004573545,0.00001594958,0.00001224955,0.00007059717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.163779,"threshold_uncertainty_score":0.6471424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003915238702878417,"score_gpt":0.2145820565967884,"score_spread":0.21066681789391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}