{"id":"W2897139946","doi":"10.1016/j.jalz.2018.06.1699","title":"P3‐338: AMYLOID AND MICROGLIAL ACTIVATION SYNERGY LEADS TO HYPOMETABOLISM IN AD BRAIN: MICROPET LONGITUDINAL STUDY","year":2018,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; Douglas Mental Health University Institute; Douglas College; McGill University","funders":"","keywords":"Neuroinflammation; Translocator protein; Amyloidosis; Microglia; Pathology; Amyloid (mycology); Genetically modified mouse; Positron emission tomography; Pittsburgh compound B; Medicine; Neuroscience; Internal medicine; Alzheimer's disease; Chemistry; Psychology; Transgene; Disease; Biochemistry; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002084696,0.0003639773,0.000384393,0.0004872141,0.0002946533,0.0002664916,0.0002923649,0.0003033679,0.00128057],"category_scores_gemma":[0.0001016971,0.0002262147,0.0003325548,0.0002992701,0.0002626489,0.0002847,0.0001725635,0.0005882602,0.000496083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000330797,"about_ca_system_score_gemma":0.0001454699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001990874,"about_ca_topic_score_gemma":0.002257469,"domain_scores_codex":[0.9998858,0.000007867365,0.000005467372,0.00003690771,0.00002684066,0.00003710442],"domain_scores_gemma":[0.9998971,0.00001025647,0.00003236098,0.00001326451,0.00002168974,0.00002530784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007059191,0.0001989536,0.00224708,0.00002729255,0.00001710327,0.0003644599,0.0000421761,0.00005004582,0.9942291,0.00003016341,0.00009461943,0.001993207],"study_design_scores_gemma":[0.00009063657,0.004811861,0.1737346,0.00001689149,0.0002480194,0.005361054,0.0001706951,0.002710427,0.8095499,0.0001884977,0.003071125,0.00004631868],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958603,0.0007432039,0.001914951,0.00004152273,0.00001332884,0.00004180978,0.0008658254,0.00005790504,0.0004611712],"genre_scores_gemma":[0.9912127,0.0007970987,0.002987455,0.00005293514,0.00002560909,0.0001959085,0.001261131,0.00004503223,0.003422074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001990874,"threshold_uncertainty_score":0.004283965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03910725805476517,"score_gpt":0.3283251832540913,"score_spread":0.2892179251993262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}