{"id":"W2897244226","doi":"10.1126/scisignal.aat2214","title":"Biased antagonism of CXCR4 avoids antagonist tolerance","year":2018,"lang":"en","type":"article","venue":"Science Signaling","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institute on Minority Health and Health Disparities; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; NIH Office of the Director; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism","keywords":"Chemokine receptor; Cell biology; Competitive antagonist; Chemotaxis; Receptor; Pharmacology; Antagonist; Chemokine; CXCR4 antagonist; Endocytosis; Biology; CCR1; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020914,0.0004552037,0.0006361612,0.0001893381,0.0001627654,0.0004102261,0.0004659205,0.0004994051,0.001548354],"category_scores_gemma":[0.0002275314,0.0002181668,0.0004243288,0.0001432984,0.0002329246,0.0002884738,0.0004001845,0.001240094,0.0006130951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004122806,"about_ca_system_score_gemma":0.0003444008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002827891,"about_ca_topic_score_gemma":0.0005798684,"domain_scores_codex":[0.9995683,0.00006446856,0.00003356759,0.0000727834,0.0001239651,0.0001369527],"domain_scores_gemma":[0.9998974,0.00001891521,0.00002988262,0.00001474587,0.00001629537,0.00002272478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001177186,0.00006822353,0.0001867372,0.00006512673,0.00001806707,0.00005751005,0.0000148475,0.0002543856,0.9935066,0.0003723083,0.0001254501,0.005213093],"study_design_scores_gemma":[0.0002379273,0.003023649,0.00256769,0.00001415041,0.00004387195,0.0008903154,0.00002156593,0.002905069,0.9790478,0.0001338083,0.01109205,0.00002208864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864487,0.003315489,0.005745092,0.0002435814,0.0001076256,0.0001764867,0.0002445069,0.000125772,0.003592739],"genre_scores_gemma":[0.9847761,0.002125243,0.007724017,0.0005049161,0.00004597084,0.000183733,0.000525826,0.00003082277,0.004083289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001548354,"threshold_uncertainty_score":0.005179763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02146944728673681,"score_gpt":0.3042402425786373,"score_spread":0.2827707952919005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}