{"id":"W2897408554","doi":"10.3389/fcvm.2018.00139","title":"A New Cardiac Channelopathy: From Clinical Phenotypes to Molecular Mechanisms Associated With Nav1.5 Gating Pores","year":2018,"lang":"en","type":"review","venue":"Frontiers in Cardiovascular Medicine","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut Universitaire en Santé Mentale de Québec; Université Laval","funders":"Canadian Institutes of Health Research; Heart And Stroke Foundation Of Quebec; Heart and Stroke Foundation of Canada","keywords":"Brugada syndrome; Gating; Channelopathy; Nav1.5; Sodium channel; Long QT syndrome; Medicine; Cardiomyopathy; Dilated cardiomyopathy; Phenotype; Internal medicine; Atrial fibrillation; Periodic paralysis; Neuroscience; Cardiology; Heart failure; Biology; Chemistry; Genetics; Gene; Physiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00298045,0.001167298,0.01108281,0.0007098445,0.0001184644,0.00002035126,0.0004350882,0.001272834,0.00005293874],"category_scores_gemma":[0.002134906,0.000850711,0.003907239,0.001588302,0.0003413057,0.00006538394,0.0002016793,0.001746929,0.00006541049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005323227,"about_ca_system_score_gemma":0.001203952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002754437,"about_ca_topic_score_gemma":0.000009174321,"domain_scores_codex":[0.9924831,0.001561666,0.001623019,0.001914569,0.00136649,0.00105119],"domain_scores_gemma":[0.9960709,0.0003745439,0.0005030293,0.00195819,0.0002907934,0.0008024969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000313599,0.00008389505,0.0001785521,0.001567806,0.03339129,0.004616844,0.0003411201,0.00003702581,0.000005621694,0.00004573669,0.0323624,0.9270561],"study_design_scores_gemma":[0.005412022,0.002767048,0.0009513441,0.06648023,0.03657283,0.0002777928,0.0002338728,0.00002889735,0.000028877,0.001033898,0.8844385,0.001774671],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001212189,0.9441087,0.04801199,0.0001716889,0.004256522,0.002566187,0.0000662146,0.0001634454,0.0005340257],"genre_scores_gemma":[0.0002148827,0.97264,0.01768594,0.0007091729,0.006453194,0.0002626286,0.001409901,0.0003217465,0.0003025008],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9252815,"threshold_uncertainty_score":0.9993944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02315506052330115,"score_gpt":0.3043281968746707,"score_spread":0.2811731363513696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}