{"id":"W2897408554","doi":"10.3389/fcvm.2018.00139","title":"A New Cardiac Channelopathy: From Clinical Phenotypes to Molecular Mechanisms Associated With Nav1.5 Gating Pores","year":2018,"lang":"en","type":"review","venue":"Frontiers in Cardiovascular Medicine","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut Universitaire en Santé Mentale de Québec; Université Laval","funders":"Canadian Institutes of Health Research; Heart And Stroke Foundation Of Quebec; Heart and Stroke Foundation of Canada","keywords":"Brugada syndrome; Gating; Channelopathy; Nav1.5; Sodium channel; Long QT syndrome; Medicine; Cardiomyopathy; Dilated cardiomyopathy; Phenotype; Internal medicine; Atrial fibrillation; Periodic paralysis; Neuroscience; Cardiology; Heart failure; Biology; Chemistry; Genetics; Gene; Physiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002717553,0.0007016707,0.0009309447,0.001958957,0.0002326114,0.0007301728,0.0005511884,0.0009678925,0.002330624],"category_scores_gemma":[0.000533646,0.0001317602,0.0004243495,0.00118962,0.0005834222,0.001384625,0.0006026605,0.001645858,0.001024437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004098776,"about_ca_system_score_gemma":0.0006588086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004946626,"about_ca_topic_score_gemma":0.0007134866,"domain_scores_codex":[0.9998696,0.00001647345,0.0000277996,0.00003174569,0.00003842844,0.00001598393],"domain_scores_gemma":[0.9998125,0.00008119724,0.00003120444,0.000005360296,0.00004795473,0.00002173484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000817736,0.00006593744,0.0007036467,0.01075885,0.00007291861,0.002518776,0.000146941,0.0002883167,0.003539972,0.006679777,0.0409597,0.9341834],"study_design_scores_gemma":[0.00002983035,0.0001213707,0.002631014,0.004803389,0.0001739658,0.04618468,0.0001659009,0.0002035023,0.001108443,0.006395778,0.9381407,0.00004140958],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003821543,0.9969293,0.0003850088,0.0006846999,0.0003227485,0.000004194531,0.00002258,0.00001417954,0.001255117],"genre_scores_gemma":[0.0027681,0.9943442,0.000389459,0.0006777195,0.0007241048,0.000006447919,0.00005597374,0.000003500858,0.001030564],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002330624,"threshold_uncertainty_score":0.007796764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02315506052330115,"score_gpt":0.3043281968746707,"score_spread":0.2811731363513696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}