{"id":"W2897430921","doi":"10.1056/nejmoa1810858","title":"Maintenance Olaparib in Patients with Newly Diagnosed Advanced Ovarian Cancer","year":2018,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":2839,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"AstraZeneca","keywords":"Olaparib; Medicine; Ovarian cancer; Oncology; Chemotherapy; Internal medicine; Disease; PARP inhibitor; Cancer; Maintenance therapy; Gynecology; Poly ADP ribose polymerase; Polymerase; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007061707,0.0002501362,0.001017885,0.0001827658,0.0001850956,0.0002968526,0.0003020347,0.0003521132,0.0008945624],"category_scores_gemma":[0.001491253,0.0001608489,0.0004019103,0.0002560748,0.0002186409,0.0002694609,0.0001984126,0.0006159184,0.0001262804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002786166,"about_ca_system_score_gemma":0.0005607813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002811246,"about_ca_topic_score_gemma":0.0006402596,"domain_scores_codex":[0.9997414,0.0001234574,0.00002814636,0.00003559815,0.00004320138,0.00002835148],"domain_scores_gemma":[0.9990101,0.0003584029,0.0002900396,0.00004076201,0.00003841109,0.0002623217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3460417,0.006723715,0.2194913,0.002323983,0.001495107,0.002007678,0.0003745785,0.002370874,0.0262002,0.0002863546,0.004162297,0.3885221],"study_design_scores_gemma":[0.2341084,0.2904603,0.4374647,0.0004813688,0.001808727,0.009167729,0.0001865789,0.003141689,0.005725952,0.0006483436,0.01674468,0.00006143389],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845269,0.01372281,0.0001898358,0.0003049039,0.00007065338,0.0002369558,0.0001388869,0.00001944662,0.0007896181],"genre_scores_gemma":[0.9951501,0.003310407,0.0004996019,0.0003134015,0.0001047921,0.0002162383,0.0002176327,0.000002306767,0.0001855256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001017885,"threshold_uncertainty_score":0.003734589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01233339124823745,"score_gpt":0.2875400329087155,"score_spread":0.275206641660478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}