{"id":"W2897450736","doi":"10.1038/s41588-018-0251-4","title":"Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome","year":2018,"lang":"en","type":"letter","venue":"Nature Genetics","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":218,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill Genome Centre; Montreal Children's Hospital; McGill University and Génome Québec Innovation Centre; Ontario Genomics; Sinai Health System; McGill University Health Centre; Lunenfeld-Tanenbaum Research Institute; University of Toronto; McGill University","funders":"Nature; Agence Nationale de la Recherche; Fonds de Recherche du Québec - Santé; European Bioinformatics Institute","keywords":"Biology; Germline; Germline mutation; Cancer research; Mutation; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.0001158248,0.0009360358,0.001052297,0.0002954835,0.000393409,0.00007480238,0.0008131976,0.004831366,0.001121739],"category_scores_gemma":[0.00002449432,0.0008207588,0.0002580662,0.0003122643,0.0006825162,0.00004361012,0.0001986709,0.002914495,0.000896095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005606465,"about_ca_system_score_gemma":0.0007277207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005760526,"about_ca_topic_score_gemma":0.00004716048,"domain_scores_codex":[0.9964043,0.0002295178,0.000677152,0.001273597,0.0001635338,0.001251828],"domain_scores_gemma":[0.9977663,0.0001650311,0.0005543358,0.001081964,0.0003630455,0.00006936222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007850411,0.0003913358,0.0008152089,0.001268069,0.002032587,0.01511137,0.0005454256,0.00003867816,0.06533593,0.00001058089,0.9107707,0.002895055],"study_design_scores_gemma":[0.002387203,0.001724523,0.002262329,0.0001859669,0.0006617664,0.03225492,0.00002488865,0.00001325784,0.00752045,0.00004551991,0.9516849,0.001234294],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.912322,0.04572565,0.0001611563,0.02181856,0.01336371,0.001619771,0.002475102,0.0005359051,0.001978154],"genre_scores_gemma":[0.8122584,0.0008227465,0.0008461963,0.1468074,0.002492251,0.0001636741,0.01045532,0.0003032217,0.02585075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1249888,"threshold_uncertainty_score":0.9998818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006547247083098695,"score_gpt":0.2128037752007473,"score_spread":0.2062565281176486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}