{"id":"W2897491066","doi":"10.1177/1076029618805863","title":"Associations of the SLCO1B1 Polymorphisms With Hepatic Function, Baseline Lipid Levels, and Lipid-lowering Response to Simvastatin in Patients With Hyperlipidemia","year":2018,"lang":"en","type":"article","venue":"Clinical and Applied Thrombosis/Hemostasis","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Anhui Medical University; Anhui University; National Natural Science Foundation of China","keywords":"SLCO1B1; Simvastatin; Hyperlipidemia; Genotype; Internal medicine; Haplotype; Triglyceride; Allele; Cholesterol; Medicine; Alanine transaminase; Aspartate transaminase; Endocrinology; Pharmacology; Chemistry; Pharmacogenetics; Gene; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001153103,0.0002572018,0.0007481013,0.00009416555,0.0001941927,0.00001750479,0.0001037502,0.0001533436,0.00005843764],"category_scores_gemma":[0.0002426216,0.000151935,0.00007139611,0.0005712984,0.0004501658,0.00005516132,0.00006110967,0.0002895654,0.000005477204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003528175,"about_ca_system_score_gemma":0.0001286941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000296374,"about_ca_topic_score_gemma":0.0002584326,"domain_scores_codex":[0.9978859,0.0001057062,0.0007874913,0.0005052218,0.0003962484,0.0003193828],"domain_scores_gemma":[0.9984035,0.0005333021,0.0002436157,0.0003857275,0.0001888908,0.0002448938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006556191,0.0007216301,0.9766113,0.00007063149,0.0001935513,9.882003e-7,0.0005914769,0.000007130224,0.004299026,0.0001811413,0.0002102587,0.01055667],"study_design_scores_gemma":[0.004414229,0.001357206,0.9893645,0.0003325509,0.0002950701,7.018573e-7,0.0002404937,0.00002007802,0.003038604,0.0000734782,0.00064793,0.0002151752],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955573,0.00001783872,0.001310003,0.001867583,0.000159643,0.0007752226,0.0001114798,0.00003376048,0.0001671772],"genre_scores_gemma":[0.9949125,0.00001297095,0.003124088,0.001596987,0.0001557393,0.0000310408,0.00003142663,0.00003834796,0.00009692325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01275318,"threshold_uncertainty_score":0.6195728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03499025040921593,"score_gpt":0.2955316808504486,"score_spread":0.2605414304412327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}