{"id":"W2897491066","doi":"10.1177/1076029618805863","title":"Associations of the SLCO1B1 Polymorphisms With Hepatic Function, Baseline Lipid Levels, and Lipid-lowering Response to Simvastatin in Patients With Hyperlipidemia","year":2018,"lang":"en","type":"article","venue":"Clinical and Applied Thrombosis/Hemostasis","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Anhui Medical University; Anhui University; National Natural Science Foundation of China","keywords":"SLCO1B1; Simvastatin; Hyperlipidemia; Genotype; Internal medicine; Haplotype; Triglyceride; Allele; Cholesterol; Medicine; Alanine transaminase; Aspartate transaminase; Endocrinology; Pharmacology; Chemistry; Pharmacogenetics; Gene; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005517919,0.0004257902,0.0006391341,0.0005086263,0.0003831774,0.000455515,0.0002008162,0.0005963183,0.001081389],"category_scores_gemma":[0.00119868,0.0003111757,0.0004657384,0.0006959195,0.000223888,0.0002680976,0.0001905072,0.0005424915,0.0001826304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000219745,"about_ca_system_score_gemma":0.000199148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001430727,"about_ca_topic_score_gemma":0.001708872,"domain_scores_codex":[0.9996682,0.0001096183,0.00004781926,0.00007216143,0.00005232461,0.00004985774],"domain_scores_gemma":[0.9993441,0.000178661,0.0002479694,0.00004187346,0.00006097761,0.0001264995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007562289,0.00005605856,0.9973127,0.000009923255,0.00008359108,0.0001089227,0.00003570153,0.00003886293,0.0007947808,0.000008958025,0.0000300361,0.000764146],"study_design_scores_gemma":[0.00005763613,0.0002867879,0.9985023,0.000004841376,0.00008385064,0.0003495787,0.0000651278,0.0003737307,0.0001443258,0.00002807924,0.00009943219,0.00000450674],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994279,0.0003097457,0.00005577728,0.00002878626,0.000003431916,0.000004154845,0.00005683239,0.00000146672,0.0001118565],"genre_scores_gemma":[0.9996222,0.0000734135,0.00008238726,0.00002562653,0.00001172582,0.000006012261,0.0000930997,0.000001171694,0.00008439284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001430727,"threshold_uncertainty_score":0.003617585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03499025040921593,"score_gpt":0.2955316808504486,"score_spread":0.2605414304412327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}