{"id":"W2897520394","doi":"10.1002/hep.30314","title":"Prioritization of Therapeutic Targets and Trial Design in Cirrhotic Portal Hypertension","year":2018,"lang":"en","type":"article","venue":"Hepatology","topic":"Liver Disease and Transplantation","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Food and Drug Administration","keywords":"Medicine; Cirrhosis; Portal hypertension; Decompensation; Portal venous pressure; Internal medicine; Intensive care medicine; Portopulmonary hypertension; Clinical trial; Nonalcoholic fatty liver disease; Liver disease; Gastroenterology; Disease; Fatty liver","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.07379053,0.001120492,0.003582951,0.001113321,0.0005596466,0.003890014,0.001153636,0.003389194,0.006354655],"category_scores_gemma":[0.09285834,0.0007006811,0.003648529,0.001099251,0.001002208,0.002063552,0.002119742,0.003484285,0.0009889361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001798474,"about_ca_system_score_gemma":0.004594636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002887908,"about_ca_topic_score_gemma":0.0005248527,"domain_scores_codex":[0.886072,0.1045706,0.004800763,0.001736655,0.00178522,0.001034842],"domain_scores_gemma":[0.9533019,0.03533906,0.00432465,0.002158261,0.002597758,0.002278324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.236532,0.002087067,0.01001321,0.02387155,0.015896,0.0003605537,0.0006681462,0.02465982,0.003657938,0.04090943,0.01867171,0.6226725],"study_design_scores_gemma":[0.3661812,0.06985185,0.02204318,0.01883467,0.02439509,0.0005727566,0.000606969,0.08407192,0.005759355,0.2641161,0.143176,0.0003909588],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"methods","genre_scores_codex":[0.1447305,0.3042894,0.2775703,0.0795666,0.02403661,0.1291412,0.00304959,0.001529893,0.03608588],"genre_scores_gemma":[0.6720741,0.02895643,0.1483883,0.02801193,0.005690545,0.1115656,0.001089233,0.0002743655,0.003949482],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.07379053,"threshold_uncertainty_score":0.3902463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03800397588799448,"score_gpt":0.2803128152326542,"score_spread":0.2423088393446597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}