{"id":"W2897521725","doi":"10.1016/j.redox.2018.10.004","title":"Ascorbic acid metabolites are involved in intraocular pressure control in the general population","year":2018,"lang":"en","type":"article","venue":"Redox Biology","topic":"Glaucoma and retinal disorders","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Moorfields Eye Hospital NHS Foundation Trust; Medical Research Council Canada; European Commission; King's College London; National Institute for Health and Care Research; Moorfields Eye Charity; Wellcome Trust; King’s College London; Cancer Research UK; Medical Research Council; Wellcome","keywords":"Mendelian randomization; Metabolome; Glaucoma; Intraocular pressure; Metabolite; Ascorbic acid; Metabolomics; Medicine; Population; Vitamin C; Oxidative stress; Ophthalmology; Pharmacology; Bioinformatics; Biology; Internal medicine; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007334848,0.0002835644,0.000367585,0.0006986214,0.0002898553,0.0005509941,0.0001834691,0.0004138286,0.001313472],"category_scores_gemma":[0.003075761,0.0001724375,0.0004475233,0.001254835,0.0002844363,0.0002310978,0.0003225192,0.0004073904,0.00009855226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001736478,"about_ca_system_score_gemma":0.000213689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003237751,"about_ca_topic_score_gemma":0.002580736,"domain_scores_codex":[0.9993234,0.0002958119,0.00005601468,0.0001837199,0.00009743863,0.00004371335],"domain_scores_gemma":[0.998922,0.0003194526,0.0004572804,0.0001526361,0.00008389277,0.00006478299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001239962,0.00008336576,0.9707459,0.0001002303,0.001124146,0.0001762957,0.0001195897,0.0002580541,0.005769442,0.0002928802,0.0002333607,0.01985691],"study_design_scores_gemma":[0.00001648904,0.0001585576,0.9969253,0.000009188288,0.0003282292,0.0003372908,0.00004595366,0.000645304,0.0003883671,0.0006181067,0.0005208327,0.000006202597],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910059,0.005700373,0.001323782,0.0003068759,0.00002453316,0.00001262582,0.0005040458,0.00003053244,0.001091316],"genre_scores_gemma":[0.9986503,0.0006238647,0.0004340752,0.00003494423,0.00001229494,0.000004019945,0.0001113786,0.000002382106,0.000126811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003237751,"threshold_uncertainty_score":0.006437838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009882517286097379,"score_gpt":0.2722100372158751,"score_spread":0.2623275199297777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}