{"id":"W2897528830","doi":"10.2147/dddt.s172487","title":"Antioxidative stress effects of vitamins C, E, and B&lt;sub&gt;12&lt;/sub&gt;, and their combination can protect the liver against acetaminophen-induced hepatotoxicity in rats","year":2018,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"College of Pharmacy and Nutrition, University of Saskatchewan; University of Petra","keywords":"Acetaminophen; Oxidative stress; Pharmacology; Vitamin E; In vivo; Antioxidant; Chemistry; Hepatocyte; Glutathione; Vitamin C; Lipid peroxidation; Superoxide dismutase; Hepatoprotection; Liver injury; Biochemistry; In vitro; Enzyme; Medicine; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001501017,0.0005403354,0.000383048,0.0005686163,0.0001672791,0.0001904631,0.0002145663,0.0003059419,0.001022273],"category_scores_gemma":[0.0001579711,0.0001776848,0.0002687305,0.0002137875,0.0002907535,0.0002633232,0.0001925764,0.0004932057,0.0001688983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001366324,"about_ca_system_score_gemma":0.0002995795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007527589,"about_ca_topic_score_gemma":0.001197755,"domain_scores_codex":[0.9999039,0.00001826377,0.00001613263,0.0000155892,0.00002269929,0.00002352801],"domain_scores_gemma":[0.9998283,0.00001496511,0.00006149614,0.00002046522,0.00002546851,0.00004917796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00663845,0.0006369842,0.0009442196,0.0002146654,0.00007468883,0.0000980328,0.00004255548,0.0001629216,0.9832045,0.00009094454,0.00009529525,0.007796635],"study_design_scores_gemma":[0.0001837369,0.00780185,0.005604971,0.00002893857,0.0002157801,0.0002151185,0.00007409778,0.0004144638,0.9829047,0.0000856538,0.002456156,0.0000145234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99502,0.002975626,0.001099897,0.00009721667,0.00003123912,0.00002587434,0.0001078255,0.00004670614,0.0005955425],"genre_scores_gemma":[0.9930026,0.002073707,0.002047415,0.0000684263,0.00001862275,0.00004733337,0.000219304,0.00001293658,0.002509655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001022273,"threshold_uncertainty_score":0.003419876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06731345294423799,"score_gpt":0.310410970952835,"score_spread":0.2430975180085971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}