{"id":"W2897528830","doi":"10.2147/dddt.s172487","title":"Antioxidative stress effects of vitamins C, E, and B&lt;sub&gt;12&lt;/sub&gt;, and their combination can protect the liver against acetaminophen-induced hepatotoxicity in rats","year":2018,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"College of Pharmacy and Nutrition, University of Saskatchewan; University of Petra","keywords":"Acetaminophen; Oxidative stress; Pharmacology; Vitamin E; In vivo; Antioxidant; Chemistry; Hepatocyte; Glutathione; Vitamin C; Lipid peroxidation; Superoxide dismutase; Hepatoprotection; Liver injury; Biochemistry; In vitro; Enzyme; Medicine; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001651161,0.000427848,0.000454581,0.0002475948,0.0006774389,0.00005755287,0.0001935912,0.0003525192,0.0000117437],"category_scores_gemma":[0.00006738753,0.0003217516,0.0000427363,0.0003365706,0.0004463837,0.0002262572,0.00009991357,0.0005856079,0.000004463745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008762668,"about_ca_system_score_gemma":0.0001575462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003145101,"about_ca_topic_score_gemma":0.0003410229,"domain_scores_codex":[0.9969442,0.001477027,0.0004376425,0.0005031773,0.0001973682,0.0004405513],"domain_scores_gemma":[0.9984919,0.0007570768,0.000283976,0.0001765113,0.0001446784,0.0001458417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004582859,0.0003303805,0.003851927,0.0001251073,0.000188567,0.00001101858,0.01978216,0.000002831547,0.7588941,0.0001385274,0.00003429761,0.2161828],"study_design_scores_gemma":[0.002980005,0.0003387015,0.04149559,0.0001302914,0.00002096212,0.000007375349,0.0002163386,0.001504762,0.9514976,0.0004935815,0.000936795,0.0003779952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942097,0.001327057,0.0005185351,0.0002131909,0.0003236952,0.003171351,0.00001518539,0.00005647156,0.000164791],"genre_scores_gemma":[0.994499,0.004329988,0.0001749627,0.0004518013,0.00007877432,0.0003678435,0.0000152822,0.00003172674,0.0000506733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2158048,"threshold_uncertainty_score":0.9999235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06731345294423799,"score_gpt":0.310410970952835,"score_spread":0.2430975180085971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}