{"id":"W2897580988","doi":"10.1016/j.jalz.2018.06.074","title":"P1‐072: PRE‐CLINICAL CHARACTERIZATION OF HUMANIZED, BLOOD‐BRAIN BARRIER (BBB)‐PENETRATING, AMYLOID‐β (Aβ) OLIGOMER‐TARGETING FUSION PROTEIN","year":2018,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston Health Sciences Centre; McGill University; National Research Council Canada","funders":"","keywords":"Blood–brain barrier; Western blot; Chemistry; Transgene; Fusion protein; In vivo; Genetically modified mouse; Molecular biology; Blot; Pharmacology; Recombinant DNA; Biochemistry; Biology; Central nervous system; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005461679,0.0005056365,0.0004267789,0.0001586642,0.000182687,0.0004815205,0.0003315579,0.0004919516,0.001301053],"category_scores_gemma":[0.0004683064,0.0001753004,0.0002365497,0.0002304562,0.0003831721,0.0003340486,0.0001800706,0.0007535032,0.0009866355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004002015,"about_ca_system_score_gemma":0.000389434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005123805,"about_ca_topic_score_gemma":0.0003241239,"domain_scores_codex":[0.99981,0.00004232855,0.00001473904,0.00003959968,0.00006567314,0.0000275983],"domain_scores_gemma":[0.9998566,0.00001810949,0.00003128854,0.00001869397,0.00003542624,0.00003981169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008594112,0.0007908748,0.0006210208,0.00009499615,0.00001932732,0.0002281316,0.00006682718,0.0001153623,0.991567,0.00008340685,0.0004783333,0.005075241],"study_design_scores_gemma":[0.0006760745,0.02780805,0.02115205,0.00002445887,0.0001372713,0.00593142,0.00006955979,0.001938371,0.9234276,0.0001518012,0.0186565,0.00002678168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899408,0.001996767,0.004740669,0.0001926526,0.00003961917,0.0004842893,0.001204059,0.00007992676,0.001321107],"genre_scores_gemma":[0.9830877,0.001974775,0.006344476,0.0002451028,0.00004603869,0.0003557532,0.005802482,0.00005354505,0.002090066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001301053,"threshold_uncertainty_score":0.00435245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03116826653620867,"score_gpt":0.322120046570708,"score_spread":0.2909517800344993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}